Bioactive Marine Xanthones: A Review
, Ana Laura Dias 2, Salete Reis 1, Madalena M. M. Pinto 2,3 and Carlos M. M. Afonso 2,3,*Round 1
Reviewer 1 Report
This is a really good review about the marine-derived xanthones. The structures and the activities were summarized and analyzed. One of the most outstanding is the calculation of molecular descrptors for the chemical space. Moreover, the detailed analysis of the biological activities is also attractive. I strongly suggest that it can be accepted for publication. But before that, a small question should be solved. Did the authors think about the differece of xanthones isolated from marine and terrestrial organisms. I think this should be mentioned in the conclusion part. This is an important point for the reason that the marine xanthones were selected for this review.Author Response
Please see the attachment.
Author Response File: 
Author Response.docx
Reviewer 2 Report
This manuscript summaries the structures and biological activities of xanthones isolated from the marine environment. The authors classified xanthone natural products into 5 structural categories, and discussed about their natural product-likeness and drug-likeness. Because xanthones are important family of marine natural products with a wide variety of biological activities, this review article would be of interest to the community.
Minor suggestions:
1. It should be shown which compounds are classified as complex xanthones in Fig. 1.
2. The structures of compounds 143 and 144 could be revised. In the presented structures of compounds 143 and 144, the methoxy group is overlapped with the hydroxy group.
3. Some compounds (e.g. compounds 99, 100 and 105) have not only O-heterocyclic group but also isoprenyl group. It is not clear why these compounds are classified as O-heterocyclic compounds.
Author Response
Please see the attachment.
