Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans
Abstract
:1. Introduction
2. A Brief Introduction to Quorum Sensing
3. The Competence Pathway in Streptococcus pneumoniae
4. Bacteriocin Regulation and Function in S. pneumoniae
5. A Second Bacteriocin QS System Cryptically Linked to Competence in S. pneumoniae
6. A Direct Link between blp and com Is Established in S. pneumoniae
7. The Multiple Layers of Competence Regulation in Streptococcus mutans
8. How Does Peptide-Rich Versus Peptide-Poor Medium Affect Competence and Bacteriocin QS Pathways?: “The Medium Is the Message”—Marshall McLuhan [78]
9. Steps towards Resolving the Link between BlpRH and ComRS in S. mutans
10. Additional Inputs Regulating Competence in S. mutans
11. Uncovering Conservation Patterns of Competence and Bacteriocin QS Pathways in Streptococcus: Further Indications of Regulatory Interconnectedness?
12. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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S. mutans Locus ID | Gene Product Name(s) | Function | References |
---|---|---|---|
SMU.1914c | CipB, Mutacin V, NlmC, BsmA | Type II bacteriocin | [22,23,24] |
SMU.1915 | MIP, ComC/CSP | Type II bacteriocin/pheromone | [25,26] |
SMU.286 | NlmT, ComA | Bacteriocin transporter | [11,27,28] |
SMU.287 | NlmE, ComB | NlmT accessory factor | [11,27,28] |
SMU.1916 | BlpH, ComD | Histidine kinase | [26,29] |
SMU.1917 | BlpR, ComE | Response regulator | [26,29] |
SMU.1997 | SigX, ComX | Alternative sigma factor | [30,31] |
SMU.61 | ComR | Type-II ComR; Transcriptional regulator of competence | [31] |
N/A | ComS | Pre-peptide of XIP pheromone | [31] |
SMU.1897-.1898 | CslA, ComA | ABC transporter ATP-binding protein/permease | [30,32] |
SMU.1900 | CslB, ComB | ABC transporter accessory protein | [30,32] |
SMU.381c | Smu.381c | Type-I ComR; Putative transcriptional regulator | [31] |
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Shanker, E.; Federle, M.J. Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans. Genes 2017, 8, 15. https://doi.org/10.3390/genes8010015
Shanker E, Federle MJ. Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans. Genes. 2017; 8(1):15. https://doi.org/10.3390/genes8010015
Chicago/Turabian StyleShanker, Erin, and Michael J. Federle. 2017. "Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans" Genes 8, no. 1: 15. https://doi.org/10.3390/genes8010015