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Hematology Reviews
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Hematology Reviews (renamed as Hematology Reports here since 2010) is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Confirmation of the Validity of Using Birth MCV for the Diagnosis of Alpha Thalassemia Trait

by
Akram Mehdi Al-Hilali
*,
Aisha M. Al-Jallaf
and
Sajida Chunkasseril
Hematology Unit, Pathology Department, Dubai Hospital, Dubai 50585, United Arab Emirates‎
*
Author to whom correspondence should be addressed.
Hematol. Rev. 2009, 1(2), e20; https://doi.org/10.4081/hr.2009.e20 (registering DOI)
Submission received: 18 June 2009 / Revised: 17 September 2009 / Accepted: 21 October 2009 / Published: 23 November 2009

Abstract

Thirty-four blood samples of neonates in Dubai, UAE, with an MCV below 90 fL were checked by high performance liquid chromatography (HPLC) for hemoglobin variants to confirm a previous study carried out in Western Province of Saudi Arabia which showed a very high predictive index of such MCV for alpha (α-) thalassemia minor (ATM). MCH below 30 pg was an additional factor which supported such a prediction. The Dubai study confirmed the original finding with 100% of such neonates showing Hb Barts band. A control group of 26 neonates with an MCV between 90 and 95 fl showed Hb Barts in only 11 cases (42.3%). Of these, 6 (23.1%) were preterm babies, expected to have higher MCV. Five cases (19.2%) had an MCH below 30 pg, though MCV was 90 or higher. Three of the preterm babies also had MCH below 30. The study confirmed the Saudi results in neonates. It seems very highly probable that a term neonate with MCV below 90 and MCH below 30 has ATM.
Keywords: MCV; MCH; Hb Barts; high performance liquid chromatography MCV; MCH; Hb Barts; high performance liquid chromatography

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MDPI and ACS Style

Al-Hilali, A.M.; Al-Jallaf, A.M.; Chunkasseril, S. Confirmation of the Validity of Using Birth MCV for the Diagnosis of Alpha Thalassemia Trait. Hematol. Rev. 2009, 1, e20. https://doi.org/10.4081/hr.2009.e20

AMA Style

Al-Hilali AM, Al-Jallaf AM, Chunkasseril S. Confirmation of the Validity of Using Birth MCV for the Diagnosis of Alpha Thalassemia Trait. Hematology Reviews. 2009; 1(2):e20. https://doi.org/10.4081/hr.2009.e20

Chicago/Turabian Style

Al-Hilali, Akram Mehdi, Aisha M. Al-Jallaf, and Sajida Chunkasseril. 2009. "Confirmation of the Validity of Using Birth MCV for the Diagnosis of Alpha Thalassemia Trait" Hematology Reviews 1, no. 2: e20. https://doi.org/10.4081/hr.2009.e20

APA Style

Al-Hilali, A. M., Al-Jallaf, A. M., & Chunkasseril, S. (2009). Confirmation of the Validity of Using Birth MCV for the Diagnosis of Alpha Thalassemia Trait. Hematology Reviews, 1(2), e20. https://doi.org/10.4081/hr.2009.e20

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