A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus
Abstract
:1. Introduction
2. Materials and Methods
2.1. Virus Strains
2.2. Experimental Design
2.3. Histopathology
2.4. Metabolomics Analysis
2.5. Transcriptomics Analysis
2.6. Microbiomics Analysis
2.7. Ethics Approval and Consent to Participate
3. Results
3.1. Clinical Signs and Pathology
3.2. NIBV Infection Altered Metabolic Profiling in the Kidney of Chickens
3.3. NIBV Infection Altered Transcription Profiling in the Kidney of Chickens
3.4. NIBV Infection Resulted in Gut Microbiota Dysbiosis
3.5. Correlation Analysis of Metabolomics and Transcriptomics Data
3.6. Correlation Analysis of Metabolomics and Microbiomics Data
4. Discussion
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Xu, P.; Liu, P.; Zhou, C.; Shi, Y.; Wu, Q.; Yang, Y.; Li, G.; Hu, G.; Guo, X. A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus. Viruses 2019, 11, 1070. https://doi.org/10.3390/v11111070
Xu P, Liu P, Zhou C, Shi Y, Wu Q, Yang Y, Li G, Hu G, Guo X. A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus. Viruses. 2019; 11(11):1070. https://doi.org/10.3390/v11111070
Chicago/Turabian StyleXu, Puzhi, Ping Liu, Changming Zhou, Yan Shi, Qingpeng Wu, Yitian Yang, Guyue Li, Guoliang Hu, and Xiaoquan Guo. 2019. "A Multi-Omics Study of Chicken Infected by Nephropathogenic Infectious Bronchitis Virus" Viruses 11, no. 11: 1070. https://doi.org/10.3390/v11111070