Hepatitis E Virus Drug Development
Abstract
:1. Introduction
2. Strategies to Find Novel Therapy Options
3. Drug Repurposing
3.1. 2’-C-Methylcytidine
3.2. NITD008 and GPC-N114
3.3. Ciprofloxacin and IFN-λ
3.4. Sofosbuvir
4. Screening
4.1. Plant Ethanol Extracts
4.2. Zinc
4.3. 66E2
5. Basic Research/Structure-Guided
5.1. Hammerhead Ribozymes
5.2. Peptide Conjugated Phosphorodiamidate Morpholino Oligomers
5.3. MG132
5.4. CP11
5.5. Inhibitors of Inosine-5′-Monophosphate Dehydrogenase
5.6. Silvestrol
6. Vaccine
7. Limitations, Needs, and Hopes for HEV Drug Development
Funding
Acknowledgments
Conflicts of Interest
References
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Kinast, V.; Burkard, T.L.; Todt, D.; Steinmann, E. Hepatitis E Virus Drug Development. Viruses 2019, 11, 485. https://doi.org/10.3390/v11060485
Kinast V, Burkard TL, Todt D, Steinmann E. Hepatitis E Virus Drug Development. Viruses. 2019; 11(6):485. https://doi.org/10.3390/v11060485
Chicago/Turabian StyleKinast, Volker, Thomas L Burkard, Daniel Todt, and Eike Steinmann. 2019. "Hepatitis E Virus Drug Development" Viruses 11, no. 6: 485. https://doi.org/10.3390/v11060485