Molecular Basis of the Ternary Interaction between NS1 of the 1918 Influenza A Virus, PI3K, and CRK
Abstract
:1. Introduction
2. Materials and Methods
3. Results and Discussion
3.1. The C-Terminal Tail (CTT) of 1918 Non-Structural Protein 1 (NS1) Directly Binds to CT-10 Regulator of Kinase (CRK)
3.2. The CTT of 1918 NS1 is Structurally Flexible
3.3. 1918 NS1 Forms a Ternary Complex with p85 and CRK
3.4. Molecular Basis of the High Affinity of 1918 NS1:p85 Complex and CRK
Author Contributions
Funding
Conflicts of Interest
References
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Dubrow, A.; Lin, S.; Savage, N.; Shen, Q.; Cho, J.-H. Molecular Basis of the Ternary Interaction between NS1 of the 1918 Influenza A Virus, PI3K, and CRK. Viruses 2020, 12, 338. https://doi.org/10.3390/v12030338
Dubrow A, Lin S, Savage N, Shen Q, Cho J-H. Molecular Basis of the Ternary Interaction between NS1 of the 1918 Influenza A Virus, PI3K, and CRK. Viruses. 2020; 12(3):338. https://doi.org/10.3390/v12030338
Chicago/Turabian StyleDubrow, Alyssa, Sirong Lin, Nowlan Savage, Qingliang Shen, and Jae-Hyun Cho. 2020. "Molecular Basis of the Ternary Interaction between NS1 of the 1918 Influenza A Virus, PI3K, and CRK" Viruses 12, no. 3: 338. https://doi.org/10.3390/v12030338
APA StyleDubrow, A., Lin, S., Savage, N., Shen, Q., & Cho, J. -H. (2020). Molecular Basis of the Ternary Interaction between NS1 of the 1918 Influenza A Virus, PI3K, and CRK. Viruses, 12(3), 338. https://doi.org/10.3390/v12030338