Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Case History
2.2. Diagnostic Investigation
2.3. SARS-CoV-2 and Feline Respiratory Pathogen PCRs
2.4. Virus Isolation and Titrations
2.5. In Situ Hybridization
2.6. Immunohistochemistry
2.7. Transmission Electron Microscopy
2.8. Whole Genome Sequencing and Phylogenetic Analysis
3. Results
3.1. Clinical Description and Pathological Observations
3.2. Molecular, Bacteriological and Virological Diagnostic Investigation
3.3. Characteristic COVID-19 Lesions Observed in Lung and Heart of the Affected Cat
3.4. Comparative Genomic Analysis
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Carvallo, F.R.; Martins, M.; Joshi, L.R.; Caserta, L.C.; Mitchell, P.K.; Cecere, T.; Hancock, S.; Goodrich, E.L.; Murphy, J.; Diel, D.G. Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy. Viruses 2021, 13, 1510. https://doi.org/10.3390/v13081510
Carvallo FR, Martins M, Joshi LR, Caserta LC, Mitchell PK, Cecere T, Hancock S, Goodrich EL, Murphy J, Diel DG. Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy. Viruses. 2021; 13(8):1510. https://doi.org/10.3390/v13081510
Chicago/Turabian StyleCarvallo, Francisco R., Mathias Martins, Lok R. Joshi, Leonardo C. Caserta, Patrick K. Mitchell, Thomas Cecere, Sandy Hancock, Erin L. Goodrich, Julia Murphy, and Diego G. Diel. 2021. "Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy" Viruses 13, no. 8: 1510. https://doi.org/10.3390/v13081510
APA StyleCarvallo, F. R., Martins, M., Joshi, L. R., Caserta, L. C., Mitchell, P. K., Cecere, T., Hancock, S., Goodrich, E. L., Murphy, J., & Diel, D. G. (2021). Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy. Viruses, 13(8), 1510. https://doi.org/10.3390/v13081510