Retroviral RNA Processing
Biology Department, Johns Hopkins University, Baltimore, MD 21218, USA
Viruses 2022, 14(5), 1113; https://doi.org/10.3390/v14051113
Submission received: 29 April 2022
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Revised: 20 May 2022
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Accepted: 20 May 2022
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Published: 23 May 2022
(This article belongs to the Special Issue Retroviral RNA Processing)
Abstract
This review is an accompaniment to a Special Issue on “Retroviral RNA Processing”. It discusses post-transcriptional regulation of retroviruses, ranging from the ancient foamy viruses to more modern viruses, such as HIV-1, HTLV-1, Rous sarcoma virus, murine leukemia virus, mouse mammary tumor virus, and Mason-Pfizer monkey virus. This review is not comprehensive. However, it tries to address some of the major questions in the field with examples of how different retroviruses express their genes. It is amazing that a single primary RNA transcript can have so many possible fates: genomic RNA, unspliced mRNA, and up to 50 different alternatively spliced mRNAs. This review will discuss the sorting of RNAs for packaging or translation, RNA nuclear export mechanisms, splicing, translation, RNA modifications, and avoidance of nonsense-mediated RNA decay.
Keywords:
retroviruses; foamy viruses; RNA processing; export; splicing; translation; RNA modification; NMD
Share and Cite
MDPI and ACS Style
Beemon, K.L. Retroviral RNA Processing. Viruses 2022, 14, 1113. https://doi.org/10.3390/v14051113
AMA Style
Beemon KL. Retroviral RNA Processing. Viruses. 2022; 14(5):1113. https://doi.org/10.3390/v14051113
Chicago/Turabian StyleBeemon, Karen L. 2022. "Retroviral RNA Processing" Viruses 14, no. 5: 1113. https://doi.org/10.3390/v14051113
APA StyleBeemon, K. L. (2022). Retroviral RNA Processing. Viruses, 14(5), 1113. https://doi.org/10.3390/v14051113
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