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Viruses
Volume 15
Issue 2
10.3390/v15020411
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Review

Baculovirus Display of Peptides and Proteins for Medical Applications

by
Aaron Pavel Rodríguez-Hernández
1,
Daniel Martínez-Flores
1,
Adolfo Cruz-Reséndiz
2,
Teresa Padilla-Flores
1,
Rodrigo González-Flores
1,
Kenia Estrada
1,
Alicia Sampieri
1,
Aldo Román Camacho-Zarco
3 and
Luis Vaca
1,*
1
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
2
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
3
European Molecular Biology Laboratory, Grenoble Outstation, EMBL Grenoble, CEDEX 9, 38042 Grenoble, France
*
Author to whom correspondence should be addressed.
Viruses 2023, 15(2), 411; https://doi.org/10.3390/v15020411
Submission received: 9 January 2023 / Revised: 27 January 2023 / Accepted: 30 January 2023 / Published: 1 February 2023
(This article belongs to the Special Issue Novel Developments and Perspectives in Viral Vector Technology)
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Abstract

Baculoviridae is a large family of arthropod-infective viruses. Recombinant baculoviruses have many applications, the best known is as a system for large scale protein production in combination with insect cell cultures. More recently recombinant baculoviruses have been utilized for the display of proteins of interest with applications in medicine. In the present review we analyze the different strategies for the display of proteins and peptides on the surface of recombinant baculoviruses and provide some examples of the different proteins displayed. We analyze briefly the commercially available systems for recombinant baculovirus production and display and discuss the future of this emerging and powerful technology.
Keywords: baculovirus display; GP64; VP39; vaccines baculovirus display; GP64; VP39; vaccines
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MDPI and ACS Style

Rodríguez-Hernández, A.P.; Martínez-Flores, D.; Cruz-Reséndiz, A.; Padilla-Flores, T.; González-Flores, R.; Estrada, K.; Sampieri, A.; Camacho-Zarco, A.R.; Vaca, L. Baculovirus Display of Peptides and Proteins for Medical Applications. Viruses 2023, 15, 411. https://doi.org/10.3390/v15020411

AMA Style

Rodríguez-Hernández AP, Martínez-Flores D, Cruz-Reséndiz A, Padilla-Flores T, González-Flores R, Estrada K, Sampieri A, Camacho-Zarco AR, Vaca L. Baculovirus Display of Peptides and Proteins for Medical Applications. Viruses. 2023; 15(2):411. https://doi.org/10.3390/v15020411

Chicago/Turabian Style

Rodríguez-Hernández, Aaron Pavel, Daniel Martínez-Flores, Adolfo Cruz-Reséndiz, Teresa Padilla-Flores, Rodrigo González-Flores, Kenia Estrada, Alicia Sampieri, Aldo Román Camacho-Zarco, and Luis Vaca. 2023. "Baculovirus Display of Peptides and Proteins for Medical Applications" Viruses 15, no. 2: 411. https://doi.org/10.3390/v15020411

APA Style

Rodríguez-Hernández, A. P., Martínez-Flores, D., Cruz-Reséndiz, A., Padilla-Flores, T., González-Flores, R., Estrada, K., Sampieri, A., Camacho-Zarco, A. R., & Vaca, L. (2023). Baculovirus Display of Peptides and Proteins for Medical Applications. Viruses, 15(2), 411. https://doi.org/10.3390/v15020411

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