Next Article in Journal
Genetic and Biological Characteristics of Duck-Origin H4N6 Avian Influenza Virus Isolated in China in 2022
Next Article in Special Issue
Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review
Previous Article in Journal
Comprehensive Assessment of Inactivation Methods for Madariaga Virus
Previous Article in Special Issue
Subconfluent ARPE-19 Cells Display Mesenchymal Cell-State Characteristics and Behave like Fibroblasts, Rather Than Epithelial Cells, in Experimental HCMV Infection Studies
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 16
Issue 2
10.3390/v16020208
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model

by
Dubravka Karner
1,
Daria Kvestak
1,
Berislav Lisnic
1,
Maja Cokaric Brdovcak
1,
Vanda Juranic Lisnic
1,
Paola Kucan Brlic
1,
Milena Hasan
2 and
Tihana Lenac Rovis
1,*
1
Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia
2
Cytometry and Biomarkers Unit of Technology and Service (CB TechS), Institut Pasteur, Université Paris Cité, 75015 Paris, France
*
Author to whom correspondence should be addressed.
Viruses 2024, 16(2), 208; https://doi.org/10.3390/v16020208
Submission received: 22 December 2023 / Revised: 26 January 2024 / Accepted: 28 January 2024 / Published: 30 January 2024
(This article belongs to the Special Issue 65-Year Anniversary of the Discovery of Cytomegalovirus)
Browse Figures
Versions Notes

Abstract

Congenital human cytomegalovirus (HCMV) infection may cause life-threatening disease and permanent damage to the central nervous system. The mouse model of CMV infection is most commonly used to study mechanisms of infection and pathogenesis. While essential to limit mouse CMV (MCMV) replication, the inflammatory responses, particularly IFNγ and TNFα, cause neurodevelopmental abnormalities. Other soluble mediators of the immune response in most tissues remain largely unexplored. To address this gap, we quantified 48 soluble mediators of the immune response, including 32 cytokines, 10 chemokines, 3 growth factors/regulators, and 3 soluble receptors in the spleen, liver, lungs, and brain at 9 and 14 days postinfection (dpi). Our analysis found 25 induced molecules in the brain at 9 dpi, with an additional 8 showing statistically elevated responses at 14 dpi. Specifically, all analyzed CCL group cytokines (CCL2, CCL3, CCL4, CCL5, CCL7, and CCL11) were upregulated at 14 dpi in the brain. Furthermore, data revealed differentially regulated analytes across tissues, such as CCL11, CXCL5, and IL-10 in the brain, IL-33/IL-33R in the liver, and VEGF-a and IL-5 in the lungs. Overall, this study provides an overview of the immune dynamics of soluble mediators in congenital CMV.
Keywords: congenital human cytomegalovirus infection; HCMV; MCMV; cytokine; chemokine congenital human cytomegalovirus infection; HCMV; MCMV; cytokine; chemokine

Share and Cite

MDPI and ACS Style

Karner, D.; Kvestak, D.; Lisnic, B.; Cokaric Brdovcak, M.; Juranic Lisnic, V.; Kucan Brlic, P.; Hasan, M.; Lenac Rovis, T. Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model. Viruses 2024, 16, 208. https://doi.org/10.3390/v16020208

AMA Style

Karner D, Kvestak D, Lisnic B, Cokaric Brdovcak M, Juranic Lisnic V, Kucan Brlic P, Hasan M, Lenac Rovis T. Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model. Viruses. 2024; 16(2):208. https://doi.org/10.3390/v16020208

Chicago/Turabian Style

Karner, Dubravka, Daria Kvestak, Berislav Lisnic, Maja Cokaric Brdovcak, Vanda Juranic Lisnic, Paola Kucan Brlic, Milena Hasan, and Tihana Lenac Rovis. 2024. "Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model" Viruses 16, no. 2: 208. https://doi.org/10.3390/v16020208

APA Style

Karner, D., Kvestak, D., Lisnic, B., Cokaric Brdovcak, M., Juranic Lisnic, V., Kucan Brlic, P., Hasan, M., & Lenac Rovis, T. (2024). Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model. Viruses, 16(2), 208. https://doi.org/10.3390/v16020208

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop