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Volume 16
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10.3390/v16071098
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Cross-Neutralizing Anti-Chikungunya and Anti-Dengue 2 IgG Antibodies from Patients and BALB/c Mice against Dengue and Chikungunya Viruses

by
Araceli Posadas-Mondragón
1,†,
José Angel Santiago-Cruz
1,2,†,
Angélica Pérez-Juárez
1,
Norma Estela Herrera-González
1,
Sara M. Sosa-Delgado
1,
Claudia Elena Wong-Arámbula
3,
Abril Paulina Rodríguez-Maldonado
3,
Mauricio Vázquez-Pichardo
4,
Daniel Duran-Ayala
4 and
José Leopoldo Aguilar-Faisal
1,*
1
Laboratorio de Medicina de Conservación de la Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico
2
Laboratorio de Ecología Microbiana, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico
3
Laboratorio de Genoma de Patógenos, Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE) “Dr. Manuel Martínez Báez”, Secretaría de Salud, Mexico City 01480, Mexico
4
Laboratorio de Arbovirus, Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE) “Dr. Manuel Martínez Báez”, Secretaría de Salud, Mexico City 01480, Mexico
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Viruses 2024, 16(7), 1098; https://doi.org/10.3390/v16071098
Submission received: 27 February 2024 / Revised: 14 May 2024 / Accepted: 5 July 2024 / Published: 8 July 2024
(This article belongs to the Special Issue New Advances in Arbovirus Vaccines)
Review Reports Versions Notes

Abstract

Dengue (DENV) and Chikungunya (CHIKV) viruses can be transmitted simultaneously by Aedes mosquitoes, and there may be co-infections in humans. However, how the adaptive immune response is modified in the host has yet to be known entirely. In this study, we analyzed the cross-reactivity and neutralizing activity of IgG antibodies against DENV and CHIKV in sera of patients from the Mexican Institute of Social Security in Veracruz, Mexico, collected in 2013 and 2015 and using IgG antibodies of BALB/c mice inoculated with DENV and/or CHIKV. Mice first inoculated with DENV and then with CHIKV produced IgG antibodies that neutralized both viruses. Mice were inoculated with CHIKV, and then with DENV; they had IgG antibodies with more significant anti-CHIKV IgG antibody neutralizing activity. However, the inoculation only with CHIKV resulted in better neutralization of DENV2. In sera obtained from patients in 2013, significant cross-reactivity and low anti-CHIKV IgG antibody neutralizing activity were observed. In CHIKV-positive 2015 sera, the anti-DENV IgG antibody neutralizing activity was high. These results suggest that CHIKV stimulates DENV2-induced memory responses and vice versa. Furthermore, cross-reactivity between the two viruses generated neutralizing antibodies, but exchanging CHIKV for DENV2 generated a better anti-CHIKV neutralizing response.
Keywords: dengue virus; Chikungunya virus; cross-reactivity; neutralizing capacity; co-infection; arbovirus; Flavivirus; Alphavirus dengue virus; Chikungunya virus; cross-reactivity; neutralizing capacity; co-infection; arbovirus; Flavivirus; Alphavirus

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MDPI and ACS Style

Posadas-Mondragón, A.; Santiago-Cruz, J.A.; Pérez-Juárez, A.; Herrera-González, N.E.; Sosa-Delgado, S.M.; Wong-Arámbula, C.E.; Rodríguez-Maldonado, A.P.; Vázquez-Pichardo, M.; Duran-Ayala, D.; Aguilar-Faisal, J.L. Cross-Neutralizing Anti-Chikungunya and Anti-Dengue 2 IgG Antibodies from Patients and BALB/c Mice against Dengue and Chikungunya Viruses. Viruses 2024, 16, 1098. https://doi.org/10.3390/v16071098

AMA Style

Posadas-Mondragón A, Santiago-Cruz JA, Pérez-Juárez A, Herrera-González NE, Sosa-Delgado SM, Wong-Arámbula CE, Rodríguez-Maldonado AP, Vázquez-Pichardo M, Duran-Ayala D, Aguilar-Faisal JL. Cross-Neutralizing Anti-Chikungunya and Anti-Dengue 2 IgG Antibodies from Patients and BALB/c Mice against Dengue and Chikungunya Viruses. Viruses. 2024; 16(7):1098. https://doi.org/10.3390/v16071098

Chicago/Turabian Style

Posadas-Mondragón, Araceli, José Angel Santiago-Cruz, Angélica Pérez-Juárez, Norma Estela Herrera-González, Sara M. Sosa-Delgado, Claudia Elena Wong-Arámbula, Abril Paulina Rodríguez-Maldonado, Mauricio Vázquez-Pichardo, Daniel Duran-Ayala, and José Leopoldo Aguilar-Faisal. 2024. "Cross-Neutralizing Anti-Chikungunya and Anti-Dengue 2 IgG Antibodies from Patients and BALB/c Mice against Dengue and Chikungunya Viruses" Viruses 16, no. 7: 1098. https://doi.org/10.3390/v16071098

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