Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases

Garcia-Oreja, Sara; Alvaro-Afonso, Francisco Javier; Vigara-Aranda, Paula; Paramio-Rodriguez, Guillermo; Leon-Herce, Diego; Lazaro-Martinez, Jose Luis

doi:10.3390/v16081307

Open AccessArticle

Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases

by

Sara Garcia-Oreja

¹

,

Francisco Javier Alvaro-Afonso

^1,2,*

,

Paula Vigara-Aranda

¹,

Guillermo Paramio-Rodriguez

¹,

Diego Leon-Herce

¹

and

Jose Luis Lazaro-Martinez

^1,2

¹

Facultad de Enfermería, Fisioterapia y Podología, University Podiatric Clinic, Complutense University of Madrid, 28040 Madrid, Spain

²

Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), University Podiatric Clinic, Complutense University of Madrid, 28040 Madrid, Spain

^*

Author to whom correspondence should be addressed.

Viruses 2024, 16(8), 1307; https://doi.org/10.3390/v16081307

Submission received: 12 July 2024 / Revised: 13 August 2024 / Accepted: 15 August 2024 / Published: 16 August 2024

(This article belongs to the Section Human Virology and Viral Diseases)

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Abstract

Background: There are multiple conservative treatment options for plantar warts, but none have proven to be universally effective. Nitric acid is often used empirically by podiatrists in the treatment of plantar warts. A novel medical device or topical solution of nitric–zinc complex solution (NZCS) could potentially offer an effective and safe alternative for the targeted treatment of plantar warts. Objective: To observe the rate of complete healing of NZCS in a series of plantar wart cases and to establish the minimum number of product applications and time needed for healing. This will help standardize and protocolize its use. Methods: A descriptive study was conducted involving 72 patients who exhibited symptoms of plantar warts. These patients underwent chemical treatment using a nitric–zinc complex. Results: The cure rate with NZCS was 59.2%. The average number of NZCS applications was 5.9 ± 3.0 and the mean duration of treatment was 9.4 ± 7.1 weeks. A recurrence rate of 6.7% was observed. Conclusions: The topical solution of the nitric–zinc complex is an effective treatment for plantar warts, which can be considered a first-line treatment option in the general population.

Keywords: cutaneous warts; human papillomavirus; nitric–zinc complex solution; plantar warts

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MDPI and ACS Style

Garcia-Oreja, S.; Alvaro-Afonso, F.J.; Vigara-Aranda, P.; Paramio-Rodriguez, G.; Leon-Herce, D.; Lazaro-Martinez, J.L. Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases. Viruses 2024, 16, 1307. https://doi.org/10.3390/v16081307

AMA Style

Garcia-Oreja S, Alvaro-Afonso FJ, Vigara-Aranda P, Paramio-Rodriguez G, Leon-Herce D, Lazaro-Martinez JL. Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases. Viruses. 2024; 16(8):1307. https://doi.org/10.3390/v16081307

Chicago/Turabian Style

Garcia-Oreja, Sara, Francisco Javier Alvaro-Afonso, Paula Vigara-Aranda, Guillermo Paramio-Rodriguez, Diego Leon-Herce, and Jose Luis Lazaro-Martinez. 2024. "Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases" Viruses 16, no. 8: 1307. https://doi.org/10.3390/v16081307

APA Style

Garcia-Oreja, S., Alvaro-Afonso, F. J., Vigara-Aranda, P., Paramio-Rodriguez, G., Leon-Herce, D., & Lazaro-Martinez, J. L. (2024). Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases. Viruses, 16(8), 1307. https://doi.org/10.3390/v16081307

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Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases

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