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Gastroenterology Insights
Volume 15
Issue 2
10.3390/gastroent15020023
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Article

Duodenal Adenocarcinoma: The Relationship between Type of Surgery and Site of Recurrence in a Spanish Cohort

by
Gerardo Blanco-Fernández
1,2,3,
Daniel Aparicio-López
4,
Celia Villodre
5,6,
Isabel Jaén-Torrejimeno
1,2,
Cándido F Alcázar López
5,6,
Diego López-Guerra
1,2,3,
Mario Serradilla-Martín
7,8,9,* and
José M. Ramia
5,6
1
Department of Surgery, Hospital Universitario de Badajoz, 06080 Badajoz, Spain
2
INUBE: Instituto Universitario de Investigación Biosanitaria de Extremadura, 06006 Badajoz, Spain
3
Facultad de Medicina y Ciencias de la Salud, Universidad de Extremadura, 06006 Badajoz, Spain
4
Department of Surgery, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
5
Department of Surgery, Hospital General Universitario Doctor Balmis, 03010 Alicante, Spain
6
ISABIAL: Instituto de Investigación Sanitaria y Biomédica, 03010 Alicante, Spain
7
Department of Surgery, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain
8
ibs.GRANADA: Instituto de Investigación Biosanitaria, 18012 Granada, Spain
9
School of Medicine, University of Granada, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2024, 15(2), 342-353; https://doi.org/10.3390/gastroent15020023
Submission received: 24 February 2024 / Revised: 7 April 2024 / Accepted: 18 April 2024 / Published: 24 April 2024
(This article belongs to the Section Gastrointestinal Disease)
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Abstract

We present a multicenter retrospective study of patients undergoing surgery for duodenal adenocarcinoma, from January 2010 to August 2020, in order to determine the epidemiological characteristics and the oncological results after surgical resection obtained in this rare tumor. Variables: demographics; tumor location; surgical intervention and immediate postoperative period; and post-surgical follow-up information, such as recurrence, overall survival (OS), and disease-free survival (DFS). A total of 32 patients underwent surgery. The median age was 69.74 years (IQR 60.47–79.09) and the male/female distribution was 3:1. The surgeries performed were: pancreaticoduodenectomy (PD) in 16 (50%) patients, segmental resection in 13 (40.6%), and the local excision of the lesion in three (9.4%). The R0 rate was higher in PD (86.7% vs. 42.9%; p = 0.013). The OS and DFS rate at one, three and five years was 95%, 70%, and 60% and 86%, 55%, and 48%, respectively. There was a greater trend towards recurrence in patients who did not undergo PD (53.8% vs. 25%; p = 0.14) and conservative surgery seemed to be associated with more local recurrence than PD (57.1% vs. 33.3%; p = 0.49). PD and limited resection are both valid options in the cases of non-ampullary duodenal adenocarcinoma, although PD presented lower rates of loco-regional recurrence.
Keywords: adenocarcinoma; duodenum; surgery adenocarcinoma; duodenum; surgery

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MDPI and ACS Style

Blanco-Fernández, G.; Aparicio-López, D.; Villodre, C.; Jaén-Torrejimeno, I.; Alcázar López, C.F.; López-Guerra, D.; Serradilla-Martín, M.; Ramia, J.M. Duodenal Adenocarcinoma: The Relationship between Type of Surgery and Site of Recurrence in a Spanish Cohort. Gastroenterol. Insights 2024, 15, 342-353. https://doi.org/10.3390/gastroent15020023

AMA Style

Blanco-Fernández G, Aparicio-López D, Villodre C, Jaén-Torrejimeno I, Alcázar López CF, López-Guerra D, Serradilla-Martín M, Ramia JM. Duodenal Adenocarcinoma: The Relationship between Type of Surgery and Site of Recurrence in a Spanish Cohort. Gastroenterology Insights. 2024; 15(2):342-353. https://doi.org/10.3390/gastroent15020023

Chicago/Turabian Style

Blanco-Fernández, Gerardo, Daniel Aparicio-López, Celia Villodre, Isabel Jaén-Torrejimeno, Cándido F Alcázar López, Diego López-Guerra, Mario Serradilla-Martín, and José M. Ramia. 2024. "Duodenal Adenocarcinoma: The Relationship between Type of Surgery and Site of Recurrence in a Spanish Cohort" Gastroenterology Insights 15, no. 2: 342-353. https://doi.org/10.3390/gastroent15020023

APA Style

Blanco-Fernández, G., Aparicio-López, D., Villodre, C., Jaén-Torrejimeno, I., Alcázar López, C. F., López-Guerra, D., Serradilla-Martín, M., & Ramia, J. M. (2024). Duodenal Adenocarcinoma: The Relationship between Type of Surgery and Site of Recurrence in a Spanish Cohort. Gastroenterology Insights, 15(2), 342-353. https://doi.org/10.3390/gastroent15020023

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