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Article

Thrombophilia and Abdominal Vessel Thrombosis in a Greek University Hospital: A Five Year Experience

by
Ioannis Starakis
1,*,
Elias E. Mazokopakis
2,
Athina Mougiou
1,
Angelos Koutras
1 and
Charalambos A. Gogos
1
1
Department of Internal Medicine, PatrasUniversity Hospital, Rion-Patras, Greece
2
Department of Internal Medicine, NavalHospital of Crete, Chania, Greece
*
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2010, 2(1), e2; https://doi.org/10.4081/gi.2010.e2
Submission received: 23 October 2009 / Revised: 26 December 2009 / Accepted: 27 December 2009 / Published: 18 January 2010

Abstract

Thrombophilia, either congenital or acquired, has foremost consequences in the abdominal vessels. We review here the cases of patients admitted with abdominal vessel thrombosis over a five-year period. Our data focused on gender and age at diagnosis, site of thrombosis, previous thromboembolic events, underlying conditions, and family history. Investigations included measurement of protein C, protein S, activated PC resistance, and antithrombin, and screening for factor V Leiden, prothrombin G20210A, the C677T variant of the methylenetetrahydrofolate reductase gene, and V617F JAK2 mutation, r lupus anticoagulant, antiphospholipid antibodies and paroxysmal nocturnal hemospherinouria, and also serum folate, vitamin 12, and total homocysteine concentrations. Twenty-nine patients were admitted and 18 of their family members also underwent the same thrombophilia investigations. Eighteen patients (62.1%) presented with portal vein thrombosis (PVT), five patients (17.2%) with mesenteric vein thrombosis (MVT), four patients (13.8%) with splenic vein thrombosis (SVT), and two (6.9%) patients with hepatic vein thrombosis (HVT). There was a high incidence of congenital thrombophilia (37.9%), acquired thrombophilic conditions (27.6%), or both (20.7%). Sixteen of 18 patients with PVT, four of five patients with MVT, all four patients with SVT, and one of two patients with HVT had one or more thrombophilic risk factors. In 13.8% of the patients no underlying condition was identified. We concluded that thrombophilia may have major implications in the pathogenesis of abdominal vessel thrombosis in adult life, and a thorough thrombophilia investigation should be performed in all these patients.
Keywords: abdominal vessels; thrombosis; thrombophilia abdominal vessels; thrombosis; thrombophilia

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MDPI and ACS Style

Starakis, I.; Mazokopakis, E.E.; Mougiou, A.; Koutras, A.; Gogos, C.A. Thrombophilia and Abdominal Vessel Thrombosis in a Greek University Hospital: A Five Year Experience. Gastroenterol. Insights 2010, 2, e2. https://doi.org/10.4081/gi.2010.e2

AMA Style

Starakis I, Mazokopakis EE, Mougiou A, Koutras A, Gogos CA. Thrombophilia and Abdominal Vessel Thrombosis in a Greek University Hospital: A Five Year Experience. Gastroenterology Insights. 2010; 2(1):e2. https://doi.org/10.4081/gi.2010.e2

Chicago/Turabian Style

Starakis, Ioannis, Elias E. Mazokopakis, Athina Mougiou, Angelos Koutras, and Charalambos A. Gogos. 2010. "Thrombophilia and Abdominal Vessel Thrombosis in a Greek University Hospital: A Five Year Experience" Gastroenterology Insights 2, no. 1: e2. https://doi.org/10.4081/gi.2010.e2

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