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Hematology Reports
Volume 10
Issue 2
10.4081/hr.2018.7527
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Blastic Epstein-Barr Virus Associated Post-Transplant Lymphoproliferative Disorder after Allogeneic Stem Cell Transplantation for Severe Aplastic Anemia

by
Masaaki Hotta
,
Aya Nakaya
*,
Shinya Fujita
,
Atsushi Satake
,
Takahisa Nakanishi
,
Yoshiko Azuma
,
Yukie Tsubokura
,
Akiko Konishi
,
Hideaki Yoshimura
,
Tomoki Ito
,
Kazuyoshi Ishii
and
Shosaku Nomura
First Department of Internal Medicine, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka 573-1010, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2018, 10(2), 7527; https://doi.org/10.4081/hr.2018.7527
Submission received: 9 December 2017 / Revised: 20 March 2018 / Accepted: 15 May 2018 / Published: 16 May 2018

Abstract

Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication of organ transplantation. Progress has recently been made in the pathological classification of PTLD. However, the clinical course has not been clarified because of the rarity of this disease. We experienced a case of PTLD with a fulminant clinical course. The patient had been under longterm immunosuppressive treatment for aplastic anemia. He received related allogeneic hematopoietic stem cell transplantation. Soon after transplantation, he developed PTLD. According to the guidelines, we reduced immunosuppression. However, the disease course was so fulminant that there was no time for the patient to respond, and he died of multi-organ failure. There may be various clinical types of PTLD, which may include some fulminant cases. In such a case, it is not sufficient to reduce immunosuppression. The patient should be carefully observed and an appropriate individual treatment should be chosen.
Keywords: post-transplant lymphoproliferative disorder; allogeneic hematopoietic stem cell transplantation; aplastic anemia; Epstein-Barr Virus post-transplant lymphoproliferative disorder; allogeneic hematopoietic stem cell transplantation; aplastic anemia; Epstein-Barr Virus

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MDPI and ACS Style

Hotta, M.; Nakaya, A.; Fujita, S.; Satake, A.; Nakanishi, T.; Azuma, Y.; Tsubokura, Y.; Konishi, A.; Yoshimura, H.; Ito, T.; et al. Blastic Epstein-Barr Virus Associated Post-Transplant Lymphoproliferative Disorder after Allogeneic Stem Cell Transplantation for Severe Aplastic Anemia. Hematol. Rep. 2018, 10, 7527. https://doi.org/10.4081/hr.2018.7527

AMA Style

Hotta M, Nakaya A, Fujita S, Satake A, Nakanishi T, Azuma Y, Tsubokura Y, Konishi A, Yoshimura H, Ito T, et al. Blastic Epstein-Barr Virus Associated Post-Transplant Lymphoproliferative Disorder after Allogeneic Stem Cell Transplantation for Severe Aplastic Anemia. Hematology Reports. 2018; 10(2):7527. https://doi.org/10.4081/hr.2018.7527

Chicago/Turabian Style

Hotta, Masaaki, Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Akiko Konishi, Hideaki Yoshimura, Tomoki Ito, and et al. 2018. "Blastic Epstein-Barr Virus Associated Post-Transplant Lymphoproliferative Disorder after Allogeneic Stem Cell Transplantation for Severe Aplastic Anemia" Hematology Reports 10, no. 2: 7527. https://doi.org/10.4081/hr.2018.7527

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