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Hematology Reports
Volume 10
Issue 3
10.4081/hr.2018.7497
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Long-Term Complete Remission of Early Hematological Relapse after Discontinuation of Immunosuppressants Following Allogeneic Transplantation for Sezary Syndrome

by
Hiroki Hosoi
,
Kazuo Hatanaka
,
Shogo Murata
,
Toshiki Mushino
,
Kodai Kuriyama
,
Akinori Nishikawa
,
Nobuyoshi Hanaoka
,
Shinobu Tamura
,
Hideki Nakakuma
and
Takashi Sonoki
*
Department of Hematology/Oncology, Wakayama Medical University, 811-1 Kimi-idera, Wakayama 641-8510, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2018, 10(3), 7497; https://doi.org/10.4081/hr.2018.7497
Submission received: 16 November 2017 / Revised: 16 April 2018 / Accepted: 27 April 2018 / Published: 5 September 2018

Abstract

Sezary syndrome (SS) is a leukemic form of cutaneous T-cell lymphoma and is chemo-resistant. Allogeneic hematopoietic stem cell transplantation is a promising therapy for SS; however, relapse is common. Therapeutic options after relapse have not been established. We managed an SS patient with hematological relapse within one month after transplantation. After discontinuation of immunosuppressants, she achieved complete remission and remained relapse-free. The chimeric analyses of Tcells showed that the full recipient type became complete donor chimera after immunological symptoms. This clinical course suggested that discontinuation of immunosuppressants may result in a graftversus- tumor effect, leading to the eradication of lymphoma cells.
Keywords: Sezary syndrome; Allo-HSCT; Graft versus tumor effect Sezary syndrome; Allo-HSCT; Graft versus tumor effect

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MDPI and ACS Style

Hosoi, H.; Hatanaka, K.; Murata, S.; Mushino, T.; Kuriyama, K.; Nishikawa, A.; Hanaoka, N.; Tamura, S.; Nakakuma, H.; Sonoki, T. Long-Term Complete Remission of Early Hematological Relapse after Discontinuation of Immunosuppressants Following Allogeneic Transplantation for Sezary Syndrome. Hematol. Rep. 2018, 10, 7497. https://doi.org/10.4081/hr.2018.7497

AMA Style

Hosoi H, Hatanaka K, Murata S, Mushino T, Kuriyama K, Nishikawa A, Hanaoka N, Tamura S, Nakakuma H, Sonoki T. Long-Term Complete Remission of Early Hematological Relapse after Discontinuation of Immunosuppressants Following Allogeneic Transplantation for Sezary Syndrome. Hematology Reports. 2018; 10(3):7497. https://doi.org/10.4081/hr.2018.7497

Chicago/Turabian Style

Hosoi, Hiroki, Kazuo Hatanaka, Shogo Murata, Toshiki Mushino, Kodai Kuriyama, Akinori Nishikawa, Nobuyoshi Hanaoka, Shinobu Tamura, Hideki Nakakuma, and Takashi Sonoki. 2018. "Long-Term Complete Remission of Early Hematological Relapse after Discontinuation of Immunosuppressants Following Allogeneic Transplantation for Sezary Syndrome" Hematology Reports 10, no. 3: 7497. https://doi.org/10.4081/hr.2018.7497

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