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Hematology Reports
Volume 10
Issue 4
10.4081/hr.2018.7823
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Morphologic and Immunophenotypic Features of a Case of Acute Monoblastic Leukemia with Unusual Positivity for Glycophorin-A

by
Giovanni Carulli
1,*,
Paola Sammuri
1,
Cristiana Domenichini
1,
Martina Rousseau
1,
Virginia Ottaviano
1,
Maria Immacolata Ferreri
2,
Antonio Azzarà
1,
Francesco Caracciolo
1 and
Mario Petrini
1
1
Division of Hematology, Santa Chiara Hospital, University of Pisa, Via Roma 67, I-56126 Pisa, Italy
2
Laboratory of Medical Genetics, AOUP, I-56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2018, 10(4), 7823; https://doi.org/10.4081/hr.2018.7823
Submission received: 24 August 2018 / Revised: 20 October 2018 / Accepted: 29 October 2018 / Published: 12 December 2018

Abstract

Acute monoblastic leukemia (AMoL) is characterized by cells with highly undifferentiated morphology. Cytochemistry with non-specific esterases is negative in up to 20% of cases. Immunophenotyping by flow cytometry has an essential role in diagnosing such a subtype of leukemia and a multiparametric approach with a wide monoclonal antibody panel is necessary. We describe a case of AMoL with morphology resembling either plasma blasts or very immature erythroblasts. Diagnosis was made by alpha-naphtyl-acetate esterase staining and with immunophenotyping, which was made with a wide monoclonal antibody panel. Blasts were positive for monocytic markers. Most of leukemic cells, however, were positive for Glycophorin-A. The presence of Glycophorin-A, which is considered as a specific marker of the erythroid lineage, has never been reported previously in cases of AMoL. This peculiar immunophenotype might be interpreted as deriving from a common myelo-erythroid precursor undergone leukemic transformation.
Keywords: acute monoblastic leukemia; cytomorphology; flow cytometry; glycophorin-A acute monoblastic leukemia; cytomorphology; flow cytometry; glycophorin-A

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MDPI and ACS Style

Carulli, G.; Sammuri, P.; Domenichini, C.; Rousseau, M.; Ottaviano, V.; Ferreri, M.I.; Azzarà, A.; Caracciolo, F.; Petrini, M. Morphologic and Immunophenotypic Features of a Case of Acute Monoblastic Leukemia with Unusual Positivity for Glycophorin-A. Hematol. Rep. 2018, 10, 7823. https://doi.org/10.4081/hr.2018.7823

AMA Style

Carulli G, Sammuri P, Domenichini C, Rousseau M, Ottaviano V, Ferreri MI, Azzarà A, Caracciolo F, Petrini M. Morphologic and Immunophenotypic Features of a Case of Acute Monoblastic Leukemia with Unusual Positivity for Glycophorin-A. Hematology Reports. 2018; 10(4):7823. https://doi.org/10.4081/hr.2018.7823

Chicago/Turabian Style

Carulli, Giovanni, Paola Sammuri, Cristiana Domenichini, Martina Rousseau, Virginia Ottaviano, Maria Immacolata Ferreri, Antonio Azzarà, Francesco Caracciolo, and Mario Petrini. 2018. "Morphologic and Immunophenotypic Features of a Case of Acute Monoblastic Leukemia with Unusual Positivity for Glycophorin-A" Hematology Reports 10, no. 4: 7823. https://doi.org/10.4081/hr.2018.7823

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