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Hematology Reports
Volume 11
Issue 1
10.4081/hr.2019.7732
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

The Use of Mean Platelet Volume for Distinguishing the Causes of Thrombocytopenia in Adult Patients

by
Lalita Norrasethada
1,
Wichan Khumpoo
2,
Ekarat Rattarittamrong
1,*,
Thanawat Rattanathammethee
1,
Chatree Chai-Adisaksopha
1 and
Adisak Tantiworawit
1
1
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
2
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2019, 11(1), 7732; https://doi.org/10.4081/hr.2019.7732
Submission received: 25 April 2018 / Revised: 11 January 2019 / Accepted: 25 March 2019 / Published: 29 March 2019

Abstract

Establishment and analysis of mean platelet volume (MPV) may be helpful in the discrimination between underproduction or over-destruction of platelets as the causes of thrombocytopenia. The primary objective is to find the cut-off point of MPV for distinguishing causes of thrombocytopenia. The secondary objective is to validate the cut-off value of the MPV by using bone marrow examination. Thrombocytopenic patients were enrolled in a training set and a receiving operating characteristics (ROC) curve was plotted to obtain the cut-off value of MPV. A validation set of patients was recruited to validate the cut-off value. The training set included 240 patients. Half with with underproductive (n = 120) and half with over-destructive thrombocytopenia (n = 120). The best cut-off value of MPV was 8.8 fL. The validation set included 119 patients in total, again in 2 groups, those with underproductive (n = 84) and those with overdestructive thrombocytopenia (n = 35). The sensitivity, specificity, PPV and NPV when MPV ≥ 8.8 fL indicating over-destructive thrombocytopenia were 77%, 89%, 89% and 77%, respectively. MPV is useful for differentiating the cause of thrombocytopenia. The value of MPV ≥ 8.8 fL has acceptable sensitivity and specificity for diagnosis of over-destructive thrombocytopenia.
Keywords: thrombocytopenia; mean platelet volume; underproductive thrombocytopenia; over-destructive thrombocytopenia thrombocytopenia; mean platelet volume; underproductive thrombocytopenia; over-destructive thrombocytopenia

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MDPI and ACS Style

Norrasethada, L.; Khumpoo, W.; Rattarittamrong, E.; Rattanathammethee, T.; Chai-Adisaksopha, C.; Tantiworawit, A. The Use of Mean Platelet Volume for Distinguishing the Causes of Thrombocytopenia in Adult Patients. Hematol. Rep. 2019, 11, 7732. https://doi.org/10.4081/hr.2019.7732

AMA Style

Norrasethada L, Khumpoo W, Rattarittamrong E, Rattanathammethee T, Chai-Adisaksopha C, Tantiworawit A. The Use of Mean Platelet Volume for Distinguishing the Causes of Thrombocytopenia in Adult Patients. Hematology Reports. 2019; 11(1):7732. https://doi.org/10.4081/hr.2019.7732

Chicago/Turabian Style

Norrasethada, Lalita, Wichan Khumpoo, Ekarat Rattarittamrong, Thanawat Rattanathammethee, Chatree Chai-Adisaksopha, and Adisak Tantiworawit. 2019. "The Use of Mean Platelet Volume for Distinguishing the Causes of Thrombocytopenia in Adult Patients" Hematology Reports 11, no. 1: 7732. https://doi.org/10.4081/hr.2019.7732

APA Style

Norrasethada, L., Khumpoo, W., Rattarittamrong, E., Rattanathammethee, T., Chai-Adisaksopha, C., & Tantiworawit, A. (2019). The Use of Mean Platelet Volume for Distinguishing the Causes of Thrombocytopenia in Adult Patients. Hematology Reports, 11(1), 7732. https://doi.org/10.4081/hr.2019.7732

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