COVID-19-Associated Thrombotic Thrombocytopenic Purpura: A Case Report and Systematic Review
Abstract
:1. What Is the New Aspect of Your Work?
2. What Is the Central Finding of Your Work?
3. What Is (or Could Be) the Specific Clinical Relevance of Your Work?
4. Introduction
5. Case Presentation
6. Methods
6.1. Search Strategy
6.2. Study Selection and Characteristics
6.3. Quality Assessment of Articles
7. Results
7.1. Patient Characteristics
7.2. Laboratory Parameters
7.3. Treatment
7.4. Outcome
7.5. Discussion
8. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Study/Year | Age (Years)/Gender | Comorbidities | Symptoms | Time from COVID-19 Illness to TTP Diagnosis | Steroids (Prednisone Equivalent Dose in mg/Day) | PLEX | RTX | CZB |
---|---|---|---|---|---|---|---|---|
Albiol et al. 2021 [5] | 57/F | Hypertension Breast Cancer in remission | Dry cough Anosmia Dysgeusia | Day 6 | Methylprednisone 1 mg/kg | 8 sessions | Yes | No |
Beaulieu et al. 2021 [6] | 70/M | Peripheral arterial disease, dyslipidemia | Confusion, seizure, dark urine | Day 19 | Methylprednisone 1 mg/kg | 7 sessions | No | No |
Dhingra et al. 2021 [7] | 35/F | None | Diarrhea, right hemiparesis, seizure | Day 15 | Methylprednisolone 1 g injection | 16 sessions | Yes | No |
Hindilerden et al. 2020 [8] | 74/F | HTN | Dry cough, Fatigue | Day 5 | Methylprednisolone 1 mg/kg/day | 11 sessions | No | No |
Law 2021 et al. [9] | 47/F | None | Fatigue, scleral icterus, dark urine | Day 17 | Dexamethasone (dose not mentioned) | 3 sessions | Yes | Yes |
Nicolotti et al. 2021 [10] | 44/F | Obesity, Hx of DVTs | Weakness, dizziness, abdominal discomfort, respiratory distress | Day 3 | Methylprednisolone (1 mg/kg, 5 days) | 14 sessions | Yes | Yes |
Shankar et al. 2021 [11] | 30/M | None | Low back pain, left flank pain, hematuria | Day 7 | Prednisone 1 mg/kg/day | 6 sessions | No | Yes |
Tehrani 2021 [12] | ||||||||
(i) | 25/F | Pregnant | Severe respiratory symptoms | Not mentioned | Dexamethasone 8 mg BID daily, 14 days | 10 days of sessions | No | No |
(ii) | 56/F | Locally advanced breast cancer/In remission | Severe respiratory symptoms | Not mentioned | Dexamethasone 8 mg BID daily, 14 days | 14 days of sessions exchange | Yes | No |
(iii) | 57/F | None | Severe respiratory symptoms | Not mentioned | Dexamethasone 8 mg BID daily, 14 days | 14 sessions | No | No |
(iv) | 38/M | None | Rectal bleeding | Not mentioned | Dexamethasone 8 mg BID, 21 days | 21 sessions | Yes | No |
Study/Year | Hb in g/dL | Plt Count × 103/m L | I NR | LDH (U/L) | ADAMTS13 Activity Ag (%) | ADAMTS13 Inhibitor Level (normal 12 U/mL; 0.5 BU) | ADAMTS13 Antibody Titer (Normal 15 U/mL) | CT/CXR of Lung Findings |
---|---|---|---|---|---|---|---|---|
Albiol et al. 2021 [5] | 6.9 | 13 | N/A | 1594 | 2.0% | 5.2 BU | - | CT thorax normal |
Beaulieu et al. 2021 [6] | 6.0 | 18 | 1.1 | 1422 | 10% | - | 0.5 | CXR normal |
Dhingra et al. 2021 [7] | 8.3 | 20 | N/A | 10,977 | undetectable | 3.0 BU | - | n/a |
Hindilerden et al. 2020 [8] | 6.6 | 48 | Normal | 1108 | 0.2% | 90 U/mL | - | Patchy peripheral bibasilar ground glass opacities in both lungs. MRI brain normal |
Law et al. 2021 [9] | 7.0 | 14 | 1.1 | 788 | 5.0% | 63 U/mL | - | n/a |
Nicolotti et al. 2021 [10] | 6.0 | 7 | Normal | 2961 | 5.0% | 57 U/mL | - | Interstitial pneumonia involving 25% of lung parenchyma |
Shankar et al. 2021 [11] | 13.7 | 9 | Normal | 1068 | 3.0% | 0.60 BU | - | n/a |
Tehrani et al. [12] | ||||||||
(i) | 7.0 | 10.5 | 1.4 | 3465 | 8.0% | - | 85 | Patchy infiltration |
(ii) | 6.0 | 41 | 1.2 | 1520 | 0.01% | - | 36.2 | Patchy bilateral infiltration |
(iii) | 7.9 | 98 | 1.5 | 1150 | 0.86% | - | 25.3 | Not mentioned |
(iv) | 8.0 | 5.0 | 1.3. | 545 | 0.06% | - | 14 | Patchy infiltration in the right upper lobe |
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Chaudhary, H.; Nasir, U.; Syed, K.; Labra, M.; Reggio, C.; Aziz, A.; Shah, P.; Reddy, R.; Sangha, N. COVID-19-Associated Thrombotic Thrombocytopenic Purpura: A Case Report and Systematic Review. Hematol. Rep. 2022, 14, 253-260. https://doi.org/10.3390/hematolrep14030035
Chaudhary H, Nasir U, Syed K, Labra M, Reggio C, Aziz A, Shah P, Reddy R, Sangha N. COVID-19-Associated Thrombotic Thrombocytopenic Purpura: A Case Report and Systematic Review. Hematology Reports. 2022; 14(3):253-260. https://doi.org/10.3390/hematolrep14030035
Chicago/Turabian StyleChaudhary, Haseeb, Usama Nasir, Khezar Syed, Maria Labra, Christopher Reggio, Ansar Aziz, Parin Shah, Roopika Reddy, and Navdeep Sangha. 2022. "COVID-19-Associated Thrombotic Thrombocytopenic Purpura: A Case Report and Systematic Review" Hematology Reports 14, no. 3: 253-260. https://doi.org/10.3390/hematolrep14030035