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Hematology Reports, Volume 15, Issue 4

December 2023 - 15 articles

Cover Story: Acute myeloid leukemia (AML) is a difficult-to-treat cancer that is prone to drug resistance. Chimeric antigen receptor T cell (CAR-T) therapy provides a reasonable alternative in AML that has shown great success in other diseases, such as lymphoid malignancies or non-malignant refractory systemic lupus erythematosus. AML patients have not yet responded well to current CAR-T treatments, and several clinical trials are ongoing. We provide an overview of basic concepts of CAR-T cell therapy and current approaches in AML, review current strategies to improve treatment efficacies, and analyze the antigen landscape that is targeted in AML. While CAR-T cell therapy has not come to clinical fruition, a better understanding of the mechanisms involved will provide clues on how to improve future approaches in AML. View this paper
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Articles (15)

  • Article
  • Open Access
2,082 Views
10 Pages

Humoral and Cell-Mediated Responses to SARS-CoV-2 Vaccination in a Cohort of Immunodeficient Patients

  • Federica Plano,
  • Mojtaba Shekarkar Azgomi,
  • Anna Maria Corsale,
  • Corinne Spoto,
  • Nadia Caccamo,
  • Serena Meraviglia,
  • Francesco Dieli,
  • Paolo D’Angelo,
  • Antonino Trizzino and
  • Sergio Siragusa

8 December 2023

This study delves into the intricate landscape of SARS-CoV-2 vaccine response in immunodeficient patients, focusing on the dynamics of both humoral and cell-mediated immunity. The cohort includes patients with common variable immunodeficiency (CVI),...

  • Review
  • Open Access
8 Citations
3,050 Views
11 Pages

Blastic Plasmocytoid Dendritic Cell Neoplasm (BPDCN): Clinical Features and Histopathology with a Therapeutic Overview

  • Gerardo Cazzato,
  • Marialessandra Capuzzolo,
  • Emilio Bellitti,
  • Giovanni De Biasi,
  • Anna Colagrande,
  • Katia Mangialardi,
  • Francesco Gaudio and
  • Giuseppe Ingravallo

8 December 2023

Blastic Plasmacytoid Dendritic Cell Neoplasms (BPDCNs) are a rare, highly aggressive hematological malignant neoplasm that primarily involve the skin, bone marrow, lymph nodes and even extra-nodal sites. The rarity and relative poor description of ca...

  • Article
  • Open Access
6 Citations
2,452 Views
12 Pages

Platelet Microvesicles, Inflammation, and Coagulation Markers: A Pilot Study

  • Antonio Gidaro,
  • Alessandro Palmerio Delitala,
  • Roberto Manetti,
  • Sonia Caccia,
  • Mark J. Soloski,
  • Giorgio Lambertenghi Deliliers,
  • Dante Castro,
  • Mattia Donadoni,
  • Arianna Bartoli and
  • Giuseppe Sanna
  • + 2 authors

4 December 2023

Background: Platelet “Microvesicles” (MVs) are studied for their role in blood coagulation and inflammation. The study aimed to establish if MVs are related to age, plasma levels of inflammation, coagulation, and fibrinolysis markers in h...

  • Review
  • Open Access
1 Citations
2,325 Views
14 Pages

26 November 2023

In Philadelphia chromosome-positive B-cell (Ph+) acute lymphoblastic leukemia (LLA), growing evidence has accumulated regarding the efficacy of low-intensity and chemo-free regimens. Our objective was to analyze all recent trials evaluating these tre...

  • Case Report
  • Open Access
2 Citations
2,430 Views
8 Pages

Angioimmunoblastic T-Cell Lymphoma after Treatment of Classic Hodgkin Lymphoma: A Case Report

  • Ken Tanaka,
  • Hiroaki Miyoshi,
  • Yusuke Yamashita,
  • Ryuta Iwamoto,
  • Yuma Yokoya,
  • Yuichi Tochino,
  • Fumiko Arakawa,
  • Shinobu Tamura,
  • Shin-Ichi Murata and
  • Takashi Sonoki
  • + 1 author

25 November 2023

We report a case of a 24-year-old man who developed angioimmunoblastic T-cell lymphoma (AITL) after treatment for refractory lymphocyte-rich classic Hodgkin lymphoma (LR-CHL). This patient was treated with the BV+AVD (brentuximab vedotin, doxorubicin...

  • Article
  • Open Access
3 Citations
2,261 Views
11 Pages

20 November 2023

Diabetes mellitus (DM) is a major public health issue worldwide. Red cell distribution width (RDW) has been reported to have predictive value in several diseases, including DM. Few data exist on the association between RDW and the prediabetic stage....

  • Review
  • Open Access
7 Citations
2,358 Views
17 Pages

20 November 2023

Methotrexate (MTX), a structurally related substance to folic acid, is an important chemotherapeutic agent used for decades in the treatment of pediatric acute lymphoblastic leukemia (ALL) and other types of cancer as non-Hodgkin lymphomas and osteos...

  • Case Report
  • Open Access
3,644 Views
7 Pages

Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock

  • Nisha Hariharan,
  • Alisha Kabadi,
  • Michelle Don,
  • Mazen Odish and
  • Benjamin Heyman

16 November 2023

Diffuse large B-cell lymphoma (DLBCL) and angioimmunoblastic T-cell lymphoma (AITL) are two subtypes of non-Hodgkin lymphoma (NHL). The simultaneous occurrence of DLBCL and AITL in a composite lymphoma is very rare, and there are no established treat...

  • Review
  • Open Access
4 Citations
4,178 Views
19 Pages

12 November 2023

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy that is often associated with relapse and drug resistance after standard chemotherapy or targeted therapy, particularly in older patients. Hematopoietic stem cell transplants ar...

  • Article
  • Open Access
3 Citations
2,889 Views
11 Pages

Management and Outcomes of Invasive Procedures in Individuals with Hemophilia A on Emicizumab Prophylaxis: A Single Center Experience

  • Karla Rener,
  • Saša Anžej Doma,
  • Martina Fink,
  • Helena Podgornik and
  • Irena Preložnik Zupan

1 November 2023

Prophylactic treatment with emicizumab has become an important and effective bleeding prevention for people with hemophilia A (PwHA). Perioperative management of PwHA using emicizumab prophylaxis is still challenging due to a lack of experience. Medi...

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Hematol. Rep. - ISSN 2038-8330Creative Common CC BY license