Next Article in Journal
Transient Stress Lymphocytosis in a Child: A Case Report and Systematic Review of the Literature
Previous Article in Journal
A Rare Onset of T-Lymphoid Blast Crisis in Chronic Myeloid Leukemia with Two Distinct Blast Populations
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Hematology Reports
Volume 16
Issue 3
10.3390/hematolrep16030041
hematolrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Double Trouble: COVID-19 Infection Exacerbates Sickle Cell Crisis Outcomes in Hospitalized Patients—Insights from National Inpatient Sample 2020

by
Zubair Hassan Bodla
1,2,
Mariam Hashmi
1,2,*,
Fatima Niaz
3,
Austin B. Auyeung
1,2,
Anuoluwa Oyetoran
1,2,
Muhammad Jahanzeb Khalil
4,
Muhammad Salman Faisal
5,
Farhan Khalid
6,
Abdel-Rahman Zakieh
1,2,
Yvette Bazikian
1,2 and
Christopher L. Bray
1,2
1
Department of Internal medicine, Graduate Medical Education, College of Medicine, University of Central Florida (UCF), Orlando, FL 32827, USA
2
Internal Medicine Residency Program, HCA Florida North Florida Hospital, Gainesville, FL 33328, USA
3
Department of Internal Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan
4
Department of Internal Medicine, University of Alabama, Montgomery, AL 36116, USA
5
Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA
6
Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2024, 16(3), 421-430; https://doi.org/10.3390/hematolrep16030041
Submission received: 13 November 2023 / Revised: 17 March 2024 / Accepted: 16 April 2024 / Published: 29 June 2024
Versions Notes

Abstract

Background: This study investigated the impact of COVID-19 on patients with sickle cell crisis (SCC) using National Inpatient Sample (NIS) data for the year 2020. Methods: A retrospective cohort analysis was conducted utilizing International Classification of Diseases (ICD-10) codes to identify adults who were admitted with a principal diagnosis of sickle cell crisis. The primary outcomes examined were inpatient mortality, while the secondary outcomes assessed included morbidity, hospital length of stay, and resource utilization. Analyses were conducted with STATA. Multivariate logistic and linear regression analyses were used to adjust for confounding variables. Results: Of 66,415 adult patients with a primary SCC diagnosis, 875 were identified with a secondary diagnosis of COVID-19 infection. Unadjusted mortality rate was higher for SCC patients with COVID-19 (2.28%) compared to those without (0.33%), with an adjusted odds ratio (aOR) of 8.49 (p = 0.001). They also showed increased odds of developing acute respiratory failure (aOR = 2.37, p = 0.003) and acute kidney injury requiring dialysis (aOR = 8.66, p = 0.034). Additionally, these patients had longer hospital stays by an adjusted mean of 3.30 days (p < 0.001) and incurred higher hospitalization charges by an adjusted mean of USD 35,578 (p = 0.005). Conclusions: The SCC patients with COVID-19 presented higher mortality rates, increased morbidity indicators, longer hospital stays, and substantial economic burdens.
Keywords: sickle cell crisis; COVID-19 complications; National Inpatient Sample (NIS); healthcare resource utilization; inpatient mortality sickle cell crisis; COVID-19 complications; National Inpatient Sample (NIS); healthcare resource utilization; inpatient mortality

Share and Cite

MDPI and ACS Style

Bodla, Z.H.; Hashmi, M.; Niaz, F.; Auyeung, A.B.; Oyetoran, A.; Khalil, M.J.; Faisal, M.S.; Khalid, F.; Zakieh, A.-R.; Bazikian, Y.; et al. Double Trouble: COVID-19 Infection Exacerbates Sickle Cell Crisis Outcomes in Hospitalized Patients—Insights from National Inpatient Sample 2020. Hematol. Rep. 2024, 16, 421-430. https://doi.org/10.3390/hematolrep16030041

AMA Style

Bodla ZH, Hashmi M, Niaz F, Auyeung AB, Oyetoran A, Khalil MJ, Faisal MS, Khalid F, Zakieh A-R, Bazikian Y, et al. Double Trouble: COVID-19 Infection Exacerbates Sickle Cell Crisis Outcomes in Hospitalized Patients—Insights from National Inpatient Sample 2020. Hematology Reports. 2024; 16(3):421-430. https://doi.org/10.3390/hematolrep16030041

Chicago/Turabian Style

Bodla, Zubair Hassan, Mariam Hashmi, Fatima Niaz, Austin B. Auyeung, Anuoluwa Oyetoran, Muhammad Jahanzeb Khalil, Muhammad Salman Faisal, Farhan Khalid, Abdel-Rahman Zakieh, Yvette Bazikian, and et al. 2024. "Double Trouble: COVID-19 Infection Exacerbates Sickle Cell Crisis Outcomes in Hospitalized Patients—Insights from National Inpatient Sample 2020" Hematology Reports 16, no. 3: 421-430. https://doi.org/10.3390/hematolrep16030041

APA Style

Bodla, Z. H., Hashmi, M., Niaz, F., Auyeung, A. B., Oyetoran, A., Khalil, M. J., Faisal, M. S., Khalid, F., Zakieh, A.-R., Bazikian, Y., & Bray, C. L. (2024). Double Trouble: COVID-19 Infection Exacerbates Sickle Cell Crisis Outcomes in Hospitalized Patients—Insights from National Inpatient Sample 2020. Hematology Reports, 16(3), 421-430. https://doi.org/10.3390/hematolrep16030041

Article Metrics

Back to TopTop