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Case Report

Severe Isoniazid Related Sideroblastic Anemia

1
Department of Medicine, Infectiology, Kantonsspital, 4600 Olten, Switzerland
2
Department of Medicine, Haematology, Kantonsspital, 4600 Olten, Switzerland
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2011, 3(1), e2; https://doi.org/10.4081/hr.2011.e2
Submission received: 30 September 2010 / Revised: 20 December 2010 / Accepted: 14 January 2011 / Published: 21 January 2011

Abstract

Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts. Anaemia rapidly resolved after cessation of Isoniazid. We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis.
Keywords: sideroblastic anaemia; isoniazid; tuberculosis sideroblastic anaemia; isoniazid; tuberculosis

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MDPI and ACS Style

Piso, R.J.; Kriz, K.; Desax, M.-C. Severe Isoniazid Related Sideroblastic Anemia. Hematol. Rep. 2011, 3, e2. https://doi.org/10.4081/hr.2011.e2

AMA Style

Piso RJ, Kriz K, Desax M-C. Severe Isoniazid Related Sideroblastic Anemia. Hematology Reports. 2011; 3(1):e2. https://doi.org/10.4081/hr.2011.e2

Chicago/Turabian Style

Piso, Rein Jan, Kveti Kriz, and Marie-Claire Desax. 2011. "Severe Isoniazid Related Sideroblastic Anemia" Hematology Reports 3, no. 1: e2. https://doi.org/10.4081/hr.2011.e2

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