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Hematology Reports
Volume 3
Issue 2
10.4081/hr.2011.e10
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

Development of Diffuse Large B-Cell Lymphoma in a Patient with Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma: Clonal Identity between Two B-Cell Neoplasms

by
Masayuki Shiseki
1,*,
Akihiro Masuda
2,
Norimichi Watanabe
3,
Masami Fujii
3,
Tomofumi Kimura
4,
Kentaro Yoshinaga
1,
Naoki Mori
1,
Masanao Teramura
1 and
Toshiko Motoji
1
1
Department of Hematolog, Tokyo Women's Medical University, 8-1, Kawada- cho, Shinjuku-ku, Tokyo 162-8666, Japan
2
Department of Surgical Pathology, Tokyo Women’s Medical University, 8-1, Kawada- cho, Shinjuku-ku, Tokyo 162-8666, Japan
3
Division of Hematology, KKR Suifu Hospital, Ibaraki 311-4141, Japan
4
Division of Hematology/Oncology and Transfusion Medicine, KKR Suifu Hospital, Ibaraki 311-4141, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2011, 3(2), e10; https://doi.org/10.4081/hr.2011.e10
Submission received: 28 May 2011 / Revised: 25 July 2011 / Accepted: 26 July 2011 / Published: 30 August 2011

Abstract

Waldenström’s macroglobulinemia (WM)/ lymphoplasmacytic lymphoma (LPL) is an indolent mature B-cell neoplasm. In rare cases of WM/LPL, diffuse large B-cell lymphoma (DLBCL) develops as a result of histologic transformation. In this report, we present a case of DLBCL developing in a patient with WM/LPL. Combination chemotherapy for DLBCL was effective and complete remission was eventually achieved. We attempted to determine the clonal relatedness between WM/LPL and DLBCL in the patient by analyzing complementarity-determining region 3 (CDR3) in the immunoglobulin heavy chain gene. A common CDR3 sequence was found in tumor cells of DLBCL and those of WM/LPL, indicating that tumor cells of DLBCL are clonally identical to those of WM/LPL. Therefore, in the present case, DLBCL is developed from WM/LPL cells by clonal evolution.
Keywords: Waldenström’s macroglobulinemia; lymphoplasmacytic lymphoma; diffuse large Bcell lymphoma; complementarity determining region 3 Waldenström’s macroglobulinemia; lymphoplasmacytic lymphoma; diffuse large Bcell lymphoma; complementarity determining region 3

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MDPI and ACS Style

Shiseki, M.; Masuda, A.; Watanabe, N.; Fujii, M.; Kimura, T.; Yoshinaga, K.; Mori, N.; Teramura, M.; Motoji, T. Development of Diffuse Large B-Cell Lymphoma in a Patient with Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma: Clonal Identity between Two B-Cell Neoplasms. Hematol. Rep. 2011, 3, e10. https://doi.org/10.4081/hr.2011.e10

AMA Style

Shiseki M, Masuda A, Watanabe N, Fujii M, Kimura T, Yoshinaga K, Mori N, Teramura M, Motoji T. Development of Diffuse Large B-Cell Lymphoma in a Patient with Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma: Clonal Identity between Two B-Cell Neoplasms. Hematology Reports. 2011; 3(2):e10. https://doi.org/10.4081/hr.2011.e10

Chicago/Turabian Style

Shiseki, Masayuki, Akihiro Masuda, Norimichi Watanabe, Masami Fujii, Tomofumi Kimura, Kentaro Yoshinaga, Naoki Mori, Masanao Teramura, and Toshiko Motoji. 2011. "Development of Diffuse Large B-Cell Lymphoma in a Patient with Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma: Clonal Identity between Two B-Cell Neoplasms" Hematology Reports 3, no. 2: e10. https://doi.org/10.4081/hr.2011.e10

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