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Hematology Reports
Volume 3
Issue 2
10.4081/hr.2011.e12
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Tricuspid Regurgitant Velocity Elevation in a Three-Year Old Child with Sickle Cell Anemia and Recurrent Acute Chest Syndromes Reversed Not by Hydroxyurea but by Bone Marrow Transplantation

by
Raffaella Colombatti
1,*,
Elena Varotto
2,
Silvia Ricato
2,
Daniel Nardo
1,
Nicola Maschietto
2,
Simone Teso
3,
Marta Pillon
4,
Chiara Messina
4,
Ornella Milanesi
2 and
Laura Sainati
1
1
Clinic of Pediatric Haematology-Oncology, Department of Pediatrics, Azienda Ospedaliera-University of Padova, Via Giustiniani 2, 35100 Padova, Italy
2
Cardiology Unit, Department of Pediatrics, Azienda Ospedaliera-University of Padova, 35100 Padova, Italy
3
University of Padova, 35100 Padova, Italy
4
Bone Marrow Transplant Unit, Clinic of Pediatric Hematology Oncology, Department of Pediatrics, Azienda Ospedaliera-University of Padova, 35100 Padova, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2011, 3(2), e12; https://doi.org/10.4081/hr.2011.e12
Submission received: 26 May 2011 / Revised: 7 August 2011 / Accepted: 8 August 2011 / Published: 1 September 2011

Abstract

Elevated Tricuspid Regurgitant Velocity (TRV) has been related to higher mortality in adults and to hemolysis, lower oxygen saturation during 6-minute walk test and acute chest syndrome (ACS) in children with sickle cell disease (SCD). Hydroxyurea (HU) has reduced TRV value in children and adults. We describe a three year old HbSS child with recurrent ACS, hypoperfusion of the left lung, mild hemolysis and persistent TRV elevation. TRV did not normalize after HU, despite improvement in clinical conditions and in baseline laboratory parameters related to hemolysis and blood viscosity, but normalized after bone marrow transplantation (BMT). Our experience suggests that in young patients, TRV reduction can be a positive concomitant effect of BMT.
Keywords: sickle-cell disease; pulmonary hypertension; tricuspid regurgitant jet velocity; hydroxyurea; bone marrow transplantation sickle-cell disease; pulmonary hypertension; tricuspid regurgitant jet velocity; hydroxyurea; bone marrow transplantation

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MDPI and ACS Style

Colombatti, R.; Varotto, E.; Ricato, S.; Nardo, D.; Maschietto, N.; Teso, S.; Pillon, M.; Messina, C.; Milanesi, O.; Sainati, L. Tricuspid Regurgitant Velocity Elevation in a Three-Year Old Child with Sickle Cell Anemia and Recurrent Acute Chest Syndromes Reversed Not by Hydroxyurea but by Bone Marrow Transplantation. Hematol. Rep. 2011, 3, e12. https://doi.org/10.4081/hr.2011.e12

AMA Style

Colombatti R, Varotto E, Ricato S, Nardo D, Maschietto N, Teso S, Pillon M, Messina C, Milanesi O, Sainati L. Tricuspid Regurgitant Velocity Elevation in a Three-Year Old Child with Sickle Cell Anemia and Recurrent Acute Chest Syndromes Reversed Not by Hydroxyurea but by Bone Marrow Transplantation. Hematology Reports. 2011; 3(2):e12. https://doi.org/10.4081/hr.2011.e12

Chicago/Turabian Style

Colombatti, Raffaella, Elena Varotto, Silvia Ricato, Daniel Nardo, Nicola Maschietto, Simone Teso, Marta Pillon, Chiara Messina, Ornella Milanesi, and Laura Sainati. 2011. "Tricuspid Regurgitant Velocity Elevation in a Three-Year Old Child with Sickle Cell Anemia and Recurrent Acute Chest Syndromes Reversed Not by Hydroxyurea but by Bone Marrow Transplantation" Hematology Reports 3, no. 2: e12. https://doi.org/10.4081/hr.2011.e12

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