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Hematology Reports
Volume 4
Issue 2
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.

Hematol. Rep., Volume 4, Issue 2 (May 2012) – 8 articles

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4 pages, 601 KiB  
Case Report
Non-Secretory Immunoglobulin E Myeloma Associated with Immunoglobulin G Monoclonal Gammopathy of Undetermined Significance
by Masako Yasuyama, Toshie Ogasawara, Kuniaki Otsuka, Motohiko Aiba and Kiyotaka Kawauchi
Hematol. Rep. 2012, 4(2), e11; https://doi.org/10.4081/hr.2012.e11 - 2 Jul 2012
Cited by 3
Abstract
A 68-year old woman came to our hospital with a severe case of anemia. Serum immunoelectropheresis identified a monoclonal immunoglobulin (Ig) G and κ protein. The serum IgE level was within the nomal range and the amounts of remaining immunogloblins were low. On [...] Read more.
A 68-year old woman came to our hospital with a severe case of anemia. Serum immunoelectropheresis identified a monoclonal immunoglobulin (Ig) G and κ protein. The serum IgE level was within the nomal range and the amounts of remaining immunogloblins were low. On bone marrow aspirate, plasma cells made up 55.5% of nucleated cells and the plasma cells showed positive readings for IgE κ and IgG by immunohistochemistry. Serum immunofixation did not reveal the IgE monoclonal band. She was diagnosed as having non-secretory IgE myeloma with IgG monoclonal gammopathy of undetermined significance. The nature of this rare myeloma will be discussed. Full article
2 pages, 632 KiB  
Article
Thrombotic Microangiopathy Associated with Bortezomib Treatment in a Patient with Relapsed Multiple Myeloma
by Urpu Salmenniemi and Kari Remes
Hematol. Rep. 2012, 4(2), e13; https://doi.org/10.4081/hr.2012.e13 - 29 Jun 2012
Cited by 19
Abstract
Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) describe microvascular occlusive disorders characterized by thrombocytopenia due to increased platelet aggregation and fragmentation hemolysis. We report here what to our knowledge is the second case of TTP/HUS associated with bortezomib treatment. Full article
3 pages, 669 KiB  
Article
Transient Ischemic Attacks as the First Presentation of JAK2-V617F Positive Chronic Myeloproliferative Neoplasm
by Fani Kalala, Antigoni Mamara, Maria Ioannou and Matthaios Speletas
Hematol. Rep. 2012, 4(2), e12; https://doi.org/10.4081/hr.2012.e12 - 29 Jun 2012
Cited by 4
Abstract
Several studies have shown that thrombotic events may underlie a latent or subclinical myeloproliferative neoplasm (MPN) and precede its definite diagnosis by 1–2 years. An early diagnosis of patients with MPN, especially those with thrombotic events in the latent MPN phase, would be [...] Read more.
Several studies have shown that thrombotic events may underlie a latent or subclinical myeloproliferative neoplasm (MPN) and precede its definite diagnosis by 1–2 years. An early diagnosis of patients with MPN, especially those with thrombotic events in the latent MPN phase, would be beneficial for their management, preventing further morbidity and improving their quality of life. For the majority of these cases, the location of thrombosis is mainly in the splanchnic major veins, while ischemic stroke and cerebral venous thrombosis are rarely observed. In this report, we present a female patient with transient ischemic attacks who suffered from a latent MPN, on the basis of a positive testing for the JAK2-V617F mutation. Full article
4 pages, 737 KiB  
Brief Report
Genotype-Phenotype Correlation of β-Thalassemia Spectrum of Mutations in an Indian Population
by Praveen Kishore Sahu, Sudhanshu Shekhar Pati and Saroj Kanti Mishra
Hematol. Rep. 2012, 4(2), e9; https://doi.org/10.4081/hr.2012.e9 - 26 Jun 2012
Cited by 6
Abstract
Coexistence of thalassemia, hemoglobinopathies and malaria has interested geneticists over many decades. The present study represents such a population from the eastern Indian state of Orissa. Children and their siblings (n = 38) were genotyped for β-thalassemia mutations and genotype-phenotype correlation was determined. [...] Read more.
Coexistence of thalassemia, hemoglobinopathies and malaria has interested geneticists over many decades. The present study represents such a population from the eastern Indian state of Orissa. Children and their siblings (n = 38) were genotyped for β-thalassemia mutations and genotype-phenotype correlation was determined. The major genotype was IVS 1.5 mutation: 26% homozygous (n = 10) and 37% (n = 14) double heterozygous with other mutations or hemoglobinopathies. Sickle hemoglobin was the major associated hemoglobinopathy (n = 12, 32%). Other mutations found were Cd 8/9, HbE and Cd 41/42. The study population did not contain any IVS 1.1 mutations which is the second major Indo-Asian genotype. Genotype-phenotype correlation revealed that genotypes of IVS 1.5, Cd 8/9 Cd 41/42 alone or in association, exhibit severe, moderate and mild severity of thalassemia, respectively. Identification of the mutation at an early age as a part of new born screening and early intervention may help reduce the thalassemia-related morbidity. Full article
2 pages, 303 KiB  
Case Report
Romiplostim as Early Treatment of Immune Thrombocytopenia with Severe Immunodeficiency
by Francesca Palandri, Nicola Polverelli, Francesca Lifrieri, Lucia Catani, Maria Benedetta Giannini, Michele Baccarani and Nicola Vianelli
Hematol. Rep. 2012, 4(2), e10; https://doi.org/10.4081/hr.2012.e10 - 26 Jun 2012
Cited by 3
Abstract
Immunosuppressive agents are the standard therapeutic approach for immune thrombocytopenia (ITP). Their prolonged use may increase the risk of infectious complications, particularly when the patient is already at higher infectious risk. In this setting, the use of drugs with a mechanism of action [...] Read more.
Immunosuppressive agents are the standard therapeutic approach for immune thrombocytopenia (ITP). Their prolonged use may increase the risk of infectious complications, particularly when the patient is already at higher infectious risk. In this setting, the use of drugs with a mechanism of action alternative to immunosuppression, like thrombopoietin receptor agonists (TRAs), may find particular indication. We report the unique case of a patient with severe immunodeficiency and ITP, who experienced a serious infectious complication while on steroids treatment, and who was successfully treated with Romiplostim second- line. The present experience supports the effectiveness and safety of TRAs as early treatment of ITP patients with drug-induced immunodeficiency or with active infections. Full article
2 pages, 83 KiB  
Article
Hematological Profile of Sickle Cell Disease from South Gujarat, India
by Sanjeev Shyam Rao, Jagdish Prasad Goyal, S. V. Raghunath and Vijay B. Shah
Hematol. Rep. 2012, 4(2), e8; https://doi.org/10.4081/hr.2012.e8 - 22 May 2012
Cited by 12
Abstract
The aim of this study was to determine hematological profile of sickle cell disease (SCD) from Surat, South Gujarat, India. This prospective cross-sectional study was conducted in the Department of Pediatrics and Sickle Cell Anemia Laboratory, Faculty of Pathology, Government Medical College, Surat, [...] Read more.
The aim of this study was to determine hematological profile of sickle cell disease (SCD) from Surat, South Gujarat, India. This prospective cross-sectional study was conducted in the Department of Pediatrics and Sickle Cell Anemia Laboratory, Faculty of Pathology, Government Medical College, Surat, India, between July 2009 and December 2010. Patients included in this study were in their steady state for a long period of time without any symptoms related to SCD or other diseases which could affect the hematological parameters. Venous blood of all patients was collected in ethylenediaminetetraacetic acid and hematological indices were measured. Thirty-three subjects homozygous in all were studied for their hematological parameters for sickle cell anemia. Moderate to severe anemia, low mean cell volume and high foetal hemoglobin dominate the hematological profile of SCD children. Full article
2 pages, 6833 KiB  
Case Report
A Case of Cutaneous Large B-Cell Lymphoma of the Legs Appearing as Chronic Venous Ulceration
by Marta Carlesimo, Diego Orsini, Alessanrdra Narcisi, Claudia Abruzzese, Giorgia Cortesi, Gabriella De Marco and Alfredo Rossi
Hematol. Rep. 2012, 4(2), e6; https://doi.org/10.4081/hr.2012.e6 - 24 Apr 2012
Cited by 2
Abstract
We report here a case of a woman with a cutaneous large B-cell lymphoma of the legs. She had a plaque lesion, superficially ulcerated and necrotized with tumorous borders situated on the posterior side of the right leg and two red or bluish-red [...] Read more.
We report here a case of a woman with a cutaneous large B-cell lymphoma of the legs. She had a plaque lesion, superficially ulcerated and necrotized with tumorous borders situated on the posterior side of the right leg and two red or bluish-red nodular lesions. A skin biopsy from both nodular and plaque lesion showed a diffuse infiltrate of atypical large B cells CD20+ and CD79a+, spanning epidermis, dermis and subcutaneous tissue. A therapeutic approach containing anti-CD20 monoclonal antibody (rituximab) was suggested. Full article
3 pages, 354 KiB  
Case Report
Adrenal Extramedullary Hematopoiesis Associated with β-Thalassemia Major
by Bijan Keikhaei, Ahmad Soltani Shirazi and Mahboob Mohammad Pour
Hematol. Rep. 2012, 4(2), e7; https://doi.org/10.4081/hr.2012.e7 - 13 Apr 2012
Cited by 15
Abstract
The presence of apparently normal hematopoietic tissue outside of bone marrow cavity is defined as extramedullary hematopoiesis (EMH). EMH is a rare complication in thalassemia major (TM) and adrenal gland as well. This report describes a case of adrenal EMH in a 26-year-old [...] Read more.
The presence of apparently normal hematopoietic tissue outside of bone marrow cavity is defined as extramedullary hematopoiesis (EMH). EMH is a rare complication in thalassemia major (TM) and adrenal gland as well. This report describes a case of adrenal EMH in a 26-year-old man with β-TM. He has been transfused with regular blood transfusion since 9 months. During the routine physical examination he was incidentally found to have a hypoechoic mass at his abdominal ultrasonography. Abdominal computed tomography scan revealed a right well-defined suprarenal mass 7.7 × 7.3 × 5.8 cm in size. The diagnosis of EMH was confirmed with ultrasonographic-guided fine needle biopsy. Treatment options which include intensified regular blood transfusion and hydroxyurea have been started. Full article
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