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Hematology Reports
Volume 5
Issue 1
10.4081/hr.2013.e1
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Article

Successful Orthotopic Liver Transplantation in an Adult Patient with Sickle Cell Disease and Review of the Literature

by
Morey Blinder
1,2,*,
B. Geng
1,
Mauricio Lisker-Melman
1,
Jeffrey S. Crippin
1,
Kevin Korenblat
1,
William Chapman
3,
Shalini Shenoy
3 and
Joshua J. Field
4
1
Division of Hematology, Department of Medicine, Washington University School of Medicine, Box 8125, 660 South Euclid Avenue, St. Louis, MO 63110, USA
2
Department of Pathology, Washington University School of Medicine, Box 8125, 660 South Euclid Avenue, St. Louis, MO 63110, USA
3
Department of Surgery, Washington University School of Medicine, Box 8125, 660 South Euclid Avenue, St. Louis, MO 63110, USA
4
Medical College of Wisconsin, Milwaukee, WI 53226, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(1), e1; https://doi.org/10.4081/hr.2013.e1
Submission received: 21 June 2012 / Revised: 28 August 2012 / Accepted: 10 September 2012 / Published: 2 May 2013

Abstract

Sickle cell disease can lead to hepatic complications ranging from acute hepatic crises to chronic liver disease including intrahepatic cholestasis, and iron overload. Although uncommon, intrahepatic cholestasis may be severe and medical treatment of this complication is often ineffective. We report a case of a 37 year-old male patient with sickle cell anemia, who developed liver failure and underwent successful orthotopic liver transplantation. Both pre and post-operatively, he was maintained on red cell transfusions. He remains stable with improved liver function 42 months post transplant. The role for orthotopic liver transplantation is not well defined in patients with sickle cell disease, and the experience remains limited. Although considerable challenges of post-transplant graft complications remain, orthotopic liver transplantation should be considered as a treatment option for sickle cell disease patients with end-stage liver disease who have progressed despite conventional medical therapy. An extended period of red cell transfusion support may lessen the post-operative complications.
Keywords: sickle cell; liver transplantation; cholestasis; transfusions sickle cell; liver transplantation; cholestasis; transfusions

Share and Cite

MDPI and ACS Style

Blinder, M.; Geng, B.; Lisker-Melman, M.; Crippin, J.S.; Korenblat, K.; Chapman, W.; Shenoy, S.; Field, J.J. Successful Orthotopic Liver Transplantation in an Adult Patient with Sickle Cell Disease and Review of the Literature. Hematol. Rep. 2013, 5, e1. https://doi.org/10.4081/hr.2013.e1

AMA Style

Blinder M, Geng B, Lisker-Melman M, Crippin JS, Korenblat K, Chapman W, Shenoy S, Field JJ. Successful Orthotopic Liver Transplantation in an Adult Patient with Sickle Cell Disease and Review of the Literature. Hematology Reports. 2013; 5(1):e1. https://doi.org/10.4081/hr.2013.e1

Chicago/Turabian Style

Blinder, Morey, B. Geng, Mauricio Lisker-Melman, Jeffrey S. Crippin, Kevin Korenblat, William Chapman, Shalini Shenoy, and Joshua J. Field. 2013. "Successful Orthotopic Liver Transplantation in an Adult Patient with Sickle Cell Disease and Review of the Literature" Hematology Reports 5, no. 1: e1. https://doi.org/10.4081/hr.2013.e1

APA Style

Blinder, M., Geng, B., Lisker-Melman, M., Crippin, J. S., Korenblat, K., Chapman, W., Shenoy, S., & Field, J. J. (2013). Successful Orthotopic Liver Transplantation in an Adult Patient with Sickle Cell Disease and Review of the Literature. Hematology Reports, 5(1), e1. https://doi.org/10.4081/hr.2013.e1

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