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Hematology Reports
Volume 5
Issue 1
10.4081/hr.2013.e5
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

A Case of Acute Promyelocytic Leukemia with Morphologic Multilineage Dysplastic Changes

by
Setsuki Isono
1,
Katsuyasu Saigo
2,*,
Keiko Nagata
1,
Keiko Numata
1,
Toshiaki Kojitani
1,
Akiharu Okamura
3,
Akihiko Nishizawa
4,
Masafumi Takata
2,
Mariko Takenokuchi
4 and
Eiji Tatsumi
5
1
Clinical Laboratory, Kakogawa West City Hospital, Kakogawa 675-0055, Japan
2
Faculty of Pharmacological Sciences, Himeji Dokkyo University, Himeji 670-8524, Japan
3
Section of Pathology, Kakogawa West City Hospital, Kakogawa 675-0055, Japan
4
Section of Internal Medicine, Kakogawa West City Hospital, Kakogawa 675-0055, Japan
5
Department of Nutrition and Health, Sagami Women’s University, Sagamihara 252-0383, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(1), e5; https://doi.org/10.4081/hr.2013.e5
Submission received: 19 September 2012 / Revised: 27 November 2012 / Accepted: 7 January 2013 / Published: 15 February 2013

Abstract

Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MDS). The patient, a 77-year-old Japanese male, was diagnosed as having pancytopenia with hematologic morphological abnormalities comprising micromegakaryocytes, neutrophils with hypo-granulation and negative peroxidase activity, and erythroblasts containing nuclei with abnormalities such as karyorrhexis. Although there is one report of a case of transformation of de novo MDS into APL and several reports of cases of therapy-related MDS transformed into APL, our patient had no history of cytopenia or of either chemo or radiation therapy. Our case can thus be considered to constitute a rare case of APL with dysplastic morphology.
Keywords: acute promyelocytic leukemia; dysplasia; all-trans retinoic acid acute promyelocytic leukemia; dysplasia; all-trans retinoic acid

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MDPI and ACS Style

Isono, S.; Saigo, K.; Nagata, K.; Numata, K.; Kojitani, T.; Okamura, A.; Nishizawa, A.; Takata, M.; Takenokuchi, M.; Tatsumi, E. A Case of Acute Promyelocytic Leukemia with Morphologic Multilineage Dysplastic Changes. Hematol. Rep. 2013, 5, e5. https://doi.org/10.4081/hr.2013.e5

AMA Style

Isono S, Saigo K, Nagata K, Numata K, Kojitani T, Okamura A, Nishizawa A, Takata M, Takenokuchi M, Tatsumi E. A Case of Acute Promyelocytic Leukemia with Morphologic Multilineage Dysplastic Changes. Hematology Reports. 2013; 5(1):e5. https://doi.org/10.4081/hr.2013.e5

Chicago/Turabian Style

Isono, Setsuki, Katsuyasu Saigo, Keiko Nagata, Keiko Numata, Toshiaki Kojitani, Akiharu Okamura, Akihiko Nishizawa, Masafumi Takata, Mariko Takenokuchi, and Eiji Tatsumi. 2013. "A Case of Acute Promyelocytic Leukemia with Morphologic Multilineage Dysplastic Changes" Hematology Reports 5, no. 1: e5. https://doi.org/10.4081/hr.2013.e5

APA Style

Isono, S., Saigo, K., Nagata, K., Numata, K., Kojitani, T., Okamura, A., Nishizawa, A., Takata, M., Takenokuchi, M., & Tatsumi, E. (2013). A Case of Acute Promyelocytic Leukemia with Morphologic Multilineage Dysplastic Changes. Hematology Reports, 5(1), e5. https://doi.org/10.4081/hr.2013.e5

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