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Hematology Reports
Volume 5
Issue 2
10.4081/hr.2013.e8
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

A Case Report of Acute Myeloid Leukemia and Neurofibromatosis 1

by
Chiara Sartor
,
Cristina Papayannidis
,
Maria Chiara Abbenante
,
Antonio Curti
,
Nicola Polverelli
,
Emanuela Ottaviani
,
Ilaria Iacobucci
,
Viviana Guadagnuolo
and
Giovanni Martinelli
*
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, via Massarenti 9, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(2), e8; https://doi.org/10.4081/hr.2013.e8
Submission received: 2 April 2013 / Revised: 11 April 2013 / Accepted: 16 April 2013 / Published: 3 July 2013

Abstract

We report a case of a 65-year old patient affected by neurofibromatosis 1, documented by the presence of germ-line mutation on the NF1 gene, who developed various hyperproliferative malignant and benign diseases. He was brought to our attention for the diagnosis of acute myeloid leukemia revealed by major fatigue and dyspnea. The disease characteristics at diagnosis were hyperleukocytosis and complex karyotype with the inversion of the chromosome 16, classifying as a high-risk leukemia. The association between leukemia and neurofibromatosis 1 is controversial and needs to be further investigated. Nevertheless, such patients present a wide number of comorbidities that make therapeutic strategies most difficult.
Keywords: acute myeloid leukemia; neurofibromatosis type 1; NF1; Von Recklinghausen disease acute myeloid leukemia; neurofibromatosis type 1; NF1; Von Recklinghausen disease

Share and Cite

MDPI and ACS Style

Sartor, C.; Papayannidis, C.; Abbenante, M.C.; Curti, A.; Polverelli, N.; Ottaviani, E.; Iacobucci, I.; Guadagnuolo, V.; Martinelli, G. A Case Report of Acute Myeloid Leukemia and Neurofibromatosis 1. Hematol. Rep. 2013, 5, e8. https://doi.org/10.4081/hr.2013.e8

AMA Style

Sartor C, Papayannidis C, Abbenante MC, Curti A, Polverelli N, Ottaviani E, Iacobucci I, Guadagnuolo V, Martinelli G. A Case Report of Acute Myeloid Leukemia and Neurofibromatosis 1. Hematology Reports. 2013; 5(2):e8. https://doi.org/10.4081/hr.2013.e8

Chicago/Turabian Style

Sartor, Chiara, Cristina Papayannidis, Maria Chiara Abbenante, Antonio Curti, Nicola Polverelli, Emanuela Ottaviani, Ilaria Iacobucci, Viviana Guadagnuolo, and Giovanni Martinelli. 2013. "A Case Report of Acute Myeloid Leukemia and Neurofibromatosis 1" Hematology Reports 5, no. 2: e8. https://doi.org/10.4081/hr.2013.e8

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