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Hematology Reports
Volume 6
Issue 1
10.4081/hr.2014.5119
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Reduced Intensity Allogeneic Stem Cell Transplant for Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm

by
Anand Lokare
1,
Emmanouil Nikolousis
2,*,
Neil Phillips
3,
Zbignieuw Rudzki
4,
Richard Lovell
2,
Bhuvan Kishore
2,
Don Milligan
2 and
Shankara Paneesha
2
1
Hematology Department, University Hospital Walsgrave, Coventry CV2 2DX, UK
2
Department of Hematology, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
3
Hematology Department, University Hopital North Staffordshire, Stoke-on-Trent ST4 7LN, UK
4
Histopathology Department, Heart of England NHS Trust, Birmingham B9 5ST, UK
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2014, 6(1), 5119; https://doi.org/10.4081/hr.2014.5119
Submission received: 8 October 2013 / Revised: 1 December 2013 / Accepted: 12 January 2014 / Published: 29 January 2014

Abstract

Blastic plasmacytoid dendritic cell neoplasm is a rare, aggressive tumor characterized by skin and/or marrow infiltration by CD4+ CD56+ cells. Historically, the tumor was variably thought to arise from either monocytes, T cells or NK cells giving rise to terms such as CD4+/CD56+ acute monoblastic leukemia, primary cutaneous CD4+/CD56+ hematodermic tumor and blastic NK-cell lymphoma. Whilst considerable progress has been made in understanding the histogenesis, the best modality of treatment remains to be defined. We are therefore reporting this case which was successfully treated with a T-deplete allogeneic transplant and the patient is currently alive and in remission 4 years post transplant.
Keywords: blastic plasmacytoid dendritic neoplasm; reduced intensity allograft; T-deplete blastic plasmacytoid dendritic neoplasm; reduced intensity allograft; T-deplete

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MDPI and ACS Style

Lokare, A.; Nikolousis, E.; Phillips, N.; Rudzki, Z.; Lovell, R.; Kishore, B.; Milligan, D.; Paneesha, S. Reduced Intensity Allogeneic Stem Cell Transplant for Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm. Hematol. Rep. 2014, 6, 5119. https://doi.org/10.4081/hr.2014.5119

AMA Style

Lokare A, Nikolousis E, Phillips N, Rudzki Z, Lovell R, Kishore B, Milligan D, Paneesha S. Reduced Intensity Allogeneic Stem Cell Transplant for Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm. Hematology Reports. 2014; 6(1):5119. https://doi.org/10.4081/hr.2014.5119

Chicago/Turabian Style

Lokare, Anand, Emmanouil Nikolousis, Neil Phillips, Zbignieuw Rudzki, Richard Lovell, Bhuvan Kishore, Don Milligan, and Shankara Paneesha. 2014. "Reduced Intensity Allogeneic Stem Cell Transplant for Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm" Hematology Reports 6, no. 1: 5119. https://doi.org/10.4081/hr.2014.5119

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