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Case Report

A Rare Cause of Acquired Immune Deficiency Syndrome Related Pancytopenia

by
Su Bin Kim
1,*,
Makeardhwaj Sarvadaman Shrivastava
1 and
Marianna Strakhan
2
1
Department of Medicine, Albert Einstein College of Medicine, Jacobi Medical Center, 1400 Pelham Parkway South, Bronx, NY 10461, USA
2
Department of Hematology/Oncology, Albert Einstein College of Medicine, Jacobi Medical Center, Bronx, NY 10461, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2015, 7(1), 5475; https://doi.org/10.4081/hr.2015.5475
Submission received: 8 May 2014 / Revised: 31 January 2015 / Accepted: 18 February 2015 / Published: 9 March 2015

Abstract

A 21-year-old male with acquired immune deficiency syndrome, not on highly active antiretroviral treatment (HAART) was admitted after complaining of headache and intermittent diarrhea, found to have Cryptococcal meningitis. During the course of his hospitalization, patient developed pancytopenia. Anemia panel, serologies including Epstein barr virus, cytomegalovirus, and parvovirus were negative. Patient then developed high grade fever with elevated liver enzymes. Blood cultures, urine cultures, stool cultures, and repeat cerebrospinal fluid cultures remained negative. Patient subsequently developed skin lesions which on biopsy showed Kaposi’s sarcoma, and upon endoscopy, noted to have gastrointestinal Kaposi’s sarcoma involvement. Human herpes virus 8 was positive. Bone marrow biopsy revealed hemophagocytic lymphohistiocytosis. Despite having a concern for patient developing immune reconstitution syndrome which may worsen his meningitis, HAART was initiated and patient’s symptoms improved including resolution of fevers and hematological as well as liver abnormalities. Kaposi’s sarcoma improved as well.
Keywords: pancytopenia; acquired immune deficiency syndrome; Kaposi sarcoma; hemophagocytic lymphohistiocytosis; abnormal liver function test pancytopenia; acquired immune deficiency syndrome; Kaposi sarcoma; hemophagocytic lymphohistiocytosis; abnormal liver function test

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MDPI and ACS Style

Kim, S.B.; Shrivastava, M.S.; Strakhan, M. A Rare Cause of Acquired Immune Deficiency Syndrome Related Pancytopenia. Hematol. Rep. 2015, 7, 5475. https://doi.org/10.4081/hr.2015.5475

AMA Style

Kim SB, Shrivastava MS, Strakhan M. A Rare Cause of Acquired Immune Deficiency Syndrome Related Pancytopenia. Hematology Reports. 2015; 7(1):5475. https://doi.org/10.4081/hr.2015.5475

Chicago/Turabian Style

Kim, Su Bin, Makeardhwaj Sarvadaman Shrivastava, and Marianna Strakhan. 2015. "A Rare Cause of Acquired Immune Deficiency Syndrome Related Pancytopenia" Hematology Reports 7, no. 1: 5475. https://doi.org/10.4081/hr.2015.5475

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