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Hematology Reports
Volume 7
Issue 3
10.4081/hr.2015.5941
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Acute Non-Atherosclerotic ST-Segment Elevation Myocardial Infarction in an Adolescent with Concurrent Hemoglobin H-Constant Spring Disease and Polycythemia Vera

by
Ekarat Rattarittamrong
1,*,
Lalita Norasetthada
1,
Adisak Tantiworawit
1,
Chatree Chai-Adisaksopha
1,
Sasinee Hantrakool
1,
Thanawat Rattanathammethee
1 and
Pimlak Charoenkwan
2
1
Division of Hematology, Department of Internal Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
2
Division of Hematology and Oncology, Department of Pediatrics, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2015, 7(3), 5941; https://doi.org/10.4081/hr.2015.5941
Submission received: 6 April 2015 / Revised: 26 June 2015 / Accepted: 29 June 2015 / Published: 23 September 2015

Abstract

Thrombosis is a major complication of polycythemia vera (PV) and also a well-known complication of thalassemia. We reported a case of non-atherosclerotic ST-segment elevation myocardial infarction (STEMI) in a 17- year-old man with concurrent post-splenectomized hemoglobin H-Constant Spring disease and JAK2 V617F mutation-positive PV. The patient initially presented with extreme thrombocytosis (platelet counts greater than 1,000,000/μL) and three months later developed an acute STEMI. Coronary artery angiography revealed an acute clot in the right coronary artery without atherosclerotic plaque. He was treated with plateletpheresis, hydroxyurea and antiplatelet agents. The platelet count decreased and his symptoms improved. This case represents the importance of early diagnosis, awareness of the increased risk for thrombotic complications, and early treatment of PV in patients who have underlying thalassemia with marked thrombocytosis.
Keywords: polycythemia vera; hemoglobin H disease; hemoglobin H-Constant Spring disease; thalassemia; myocardial infarction polycythemia vera; hemoglobin H disease; hemoglobin H-Constant Spring disease; thalassemia; myocardial infarction

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MDPI and ACS Style

Rattarittamrong, E.; Norasetthada, L.; Tantiworawit, A.; Chai-Adisaksopha, C.; Hantrakool, S.; Rattanathammethee, T.; Charoenkwan, P. Acute Non-Atherosclerotic ST-Segment Elevation Myocardial Infarction in an Adolescent with Concurrent Hemoglobin H-Constant Spring Disease and Polycythemia Vera. Hematol. Rep. 2015, 7, 5941. https://doi.org/10.4081/hr.2015.5941

AMA Style

Rattarittamrong E, Norasetthada L, Tantiworawit A, Chai-Adisaksopha C, Hantrakool S, Rattanathammethee T, Charoenkwan P. Acute Non-Atherosclerotic ST-Segment Elevation Myocardial Infarction in an Adolescent with Concurrent Hemoglobin H-Constant Spring Disease and Polycythemia Vera. Hematology Reports. 2015; 7(3):5941. https://doi.org/10.4081/hr.2015.5941

Chicago/Turabian Style

Rattarittamrong, Ekarat, Lalita Norasetthada, Adisak Tantiworawit, Chatree Chai-Adisaksopha, Sasinee Hantrakool, Thanawat Rattanathammethee, and Pimlak Charoenkwan. 2015. "Acute Non-Atherosclerotic ST-Segment Elevation Myocardial Infarction in an Adolescent with Concurrent Hemoglobin H-Constant Spring Disease and Polycythemia Vera" Hematology Reports 7, no. 3: 5941. https://doi.org/10.4081/hr.2015.5941

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