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Hematology Reports
Volume 8
Issue 2
10.4081/hr.2016.6482
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Refractory Ascites with Liver Fibrosis Developed in Late Phase Allogeneic Hematopoietic Stem Cell Transplantation: Report of Three Patients

by
Hiroki Hosoi
1,
Kenji Warigaya
2,
Shogo Murata
1,
Toshiki Mushino
1,
Kodai Kuriyama
1,
Akinori Nishikawa
1,
Shinobu Tamura
1,
Kazuo Hatanaka
1,
Nobuyoshi Hanaoka
1,
Yasuteru Muragaki
3,
Shinichi Murata
2,
Hideki Nakakuma
1 and
Takashi Sonoki
1,*
1
Department of Hematology and Oncology, Wakayama Medical University, Kimiidera 811-1, 641-8510 Wakayama, Japan
2
Department of Human Pathology and Diagnostic Pathology, Wakayama Medical University, Wakayama, Japan
3
First Department of Pathology, Wakayama Medical University, Wakayama, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2016, 8(2), 6482; https://doi.org/10.4081/hr.2016.6482
Submission received: 21 February 2016 / Revised: 14 June 2016 / Accepted: 17 June 2016 / Published: 27 June 2016

Abstract

We report cases of three patients of refractory ascites without other fluid retention that occurred around five months after allogeneic hematopoietic stem cell transplantation (allo- HSCT). All three patients expired and postmortem examinations revealed unexpected liver fibrosis lacking histological evidences of graft-versus-host-disease (GVHD). The three patients showed normal hepatic function and size before transplantation. During their clinical courses, serum biochemistry test showed no elevation of hepatic enzymes and bilirubin; however, imaging studies demonstrated hepatic atrophy at the onset of ascites. One of the liver specimens showed bile obstruction, which could be seen in hepatic damage by GVHD. Although ascites resulting from venoocclusive disease in early phase allo-HSCT is well documented, ascites associated with hepatic fibrosis in late phase allo-HCST has not been reported. Further clinico-pathological studies on similar patients should be required to ascertain refractory ascites associated with liver fibrosis after allo-HSCT.
Keywords: allo-hematopoietic stem cell transplantation; complications; liver fibrosis allo-hematopoietic stem cell transplantation; complications; liver fibrosis

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MDPI and ACS Style

Hosoi, H.; Warigaya, K.; Murata, S.; Mushino, T.; Kuriyama, K.; Nishikawa, A.; Tamura, S.; Hatanaka, K.; Hanaoka, N.; Muragaki, Y.; et al. Refractory Ascites with Liver Fibrosis Developed in Late Phase Allogeneic Hematopoietic Stem Cell Transplantation: Report of Three Patients. Hematol. Rep. 2016, 8, 6482. https://doi.org/10.4081/hr.2016.6482

AMA Style

Hosoi H, Warigaya K, Murata S, Mushino T, Kuriyama K, Nishikawa A, Tamura S, Hatanaka K, Hanaoka N, Muragaki Y, et al. Refractory Ascites with Liver Fibrosis Developed in Late Phase Allogeneic Hematopoietic Stem Cell Transplantation: Report of Three Patients. Hematology Reports. 2016; 8(2):6482. https://doi.org/10.4081/hr.2016.6482

Chicago/Turabian Style

Hosoi, Hiroki, Kenji Warigaya, Shogo Murata, Toshiki Mushino, Kodai Kuriyama, Akinori Nishikawa, Shinobu Tamura, Kazuo Hatanaka, Nobuyoshi Hanaoka, Yasuteru Muragaki, and et al. 2016. "Refractory Ascites with Liver Fibrosis Developed in Late Phase Allogeneic Hematopoietic Stem Cell Transplantation: Report of Three Patients" Hematology Reports 8, no. 2: 6482. https://doi.org/10.4081/hr.2016.6482

APA Style

Hosoi, H., Warigaya, K., Murata, S., Mushino, T., Kuriyama, K., Nishikawa, A., Tamura, S., Hatanaka, K., Hanaoka, N., Muragaki, Y., Murata, S., Nakakuma, H., & Sonoki, T. (2016). Refractory Ascites with Liver Fibrosis Developed in Late Phase Allogeneic Hematopoietic Stem Cell Transplantation: Report of Three Patients. Hematology Reports, 8(2), 6482. https://doi.org/10.4081/hr.2016.6482

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