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Hematology Reports
Volume 9
Issue 4
10.4081/hr.2017.7091
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Haploidentical Hematopoietic Stem Cell Transplantation in a Myelofibrosis Patient with Primary Graft Failure

by
Cristina Tecchio
1,*,
Angelo Andreini
1,
Claudio Costantini
1,
Alberto Zamò
2,
Donata de Sabata
1,
Fiorenza Aprili
3,
Roberta Galavotti
4,
Emanuele Guardalben
1 and
Fabio Benedetti
1
1
Section of Hematology and Bone Marrow Transplant Unit, Department of Medicine, University of Verona, Piazzale Ludovico Antonio Scuro, 10, 37134 Verona, Italy
2
Section of Pathology and Diagnostics, Department of Pathology, University of Verona, 37134 Verona, Italy
3
Clinical Biochemistry Laboratory, Department of Life and Reproduction Sciences, University of Verona, 37134 Verona, Italy
4
Section of Biology and Genetics, Department of Mother and Child, University of Verona, 37134 Verona, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2017, 9(4), 7091; https://doi.org/10.4081/hr.2017.7091
Submission received: 13 February 2017 / Revised: 6 October 2017 / Accepted: 13 October 2017 / Published: 3 January 2018

Abstract

The prognosis of patients affected by myelofibrosis (MF) is usually dismal and allogeneic hematopoietic stem cell transplantation (HSCT) remains the only cure. The number of HSCTs in MF patients has recently increased. However, a major obstacle is still represented by primary graft failure (PGF). Currently there are no definitive guidelines for the treatment of PGF and a second HSCT can be performed only when an allogeneic donor is rapidly available. Herein we report on a MF patient with PGF after an unrelated HSCT, who was rescued by a non-myeloablative, unmanipulated, haploidentical HSCT that resulted in persistent engraftment and bone-marrow fibrosis regression, but not in a long-term disease control. Based on this experience we briefly review the role of different conditioning regimens and hematopoietic stem cell sources in the setting of HSCT for MF patients with PGF. The role of haploidentical donors in MF patients lacking HLAmatched relatives is also discussed.
Keywords: primary graft failure; haploidentical hematopoietic stem cell transplantation; myelofibrosis primary graft failure; haploidentical hematopoietic stem cell transplantation; myelofibrosis

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MDPI and ACS Style

Tecchio, C.; Andreini, A.; Costantini, C.; Zamò, A.; de Sabata, D.; Aprili, F.; Galavotti, R.; Guardalben, E.; Benedetti, F. Haploidentical Hematopoietic Stem Cell Transplantation in a Myelofibrosis Patient with Primary Graft Failure. Hematol. Rep. 2017, 9, 7091. https://doi.org/10.4081/hr.2017.7091

AMA Style

Tecchio C, Andreini A, Costantini C, Zamò A, de Sabata D, Aprili F, Galavotti R, Guardalben E, Benedetti F. Haploidentical Hematopoietic Stem Cell Transplantation in a Myelofibrosis Patient with Primary Graft Failure. Hematology Reports. 2017; 9(4):7091. https://doi.org/10.4081/hr.2017.7091

Chicago/Turabian Style

Tecchio, Cristina, Angelo Andreini, Claudio Costantini, Alberto Zamò, Donata de Sabata, Fiorenza Aprili, Roberta Galavotti, Emanuele Guardalben, and Fabio Benedetti. 2017. "Haploidentical Hematopoietic Stem Cell Transplantation in a Myelofibrosis Patient with Primary Graft Failure" Hematology Reports 9, no. 4: 7091. https://doi.org/10.4081/hr.2017.7091

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