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Hematology Reports
Volume 9
Issue 4
10.4081/hr.2017.7406
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Expression of Some ATP-Binding Cassette Transporters in Acute Myeloid Leukemia

by
Antonella Maria Salvia
1,
Flavia Cuviello
1,
Sabrina Coluzzi
2,
Roberta Nuccorini
2,
Immacolata Attolico
2,
Sara Pasquina Pascale
2,
Faustino Bisaccia
1,
Michele Pizzuti
2 and
Angela Ostuni
1,*
1
Department of Sciences, University of Basilicata, Via dell’Ateneo Lucano, 85100 Potenza, Italy
2
Department of Hematology, San Carlo Hospital, 85100 Potenza, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2017, 9(4), 7406; https://doi.org/10.4081/hr.2017.7406
Submission received: 13 September 2017 / Revised: 30 September 2017 / Accepted: 18 October 2017 / Published: 22 December 2017

Abstract

Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to the superfamily of ABC transporters such as ABCB1, ABCG2 and ABCC1. Although several studies were carried out to correlate ABC transporters expression with drug resistance, little is known about their role as markers of diagnosis and progression of the disease. For this purpose we investigated the expression, by real-time PCR, of some ABC genes in bone marrow samples of AML patients at diagnosis and after induction therapy. At diagnosis, ABCG2 was always down-regulated, while an up regulated trend for ABCC1 was observed. After therapy the examined genes showed a different expression trend and approached the values of healthy subjects suggesting that this event could be considered as a marker of AML regression. The expression levels of some ABC transporters such as ABCC6, seems to be related to gender, age and to the presence of FLT3/ITD gene mutation.
Keywords: acute myeloid leukemia; multidrug resistance; ABC transporters; ABCC6 acute myeloid leukemia; multidrug resistance; ABC transporters; ABCC6

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MDPI and ACS Style

Salvia, A.M.; Cuviello, F.; Coluzzi, S.; Nuccorini, R.; Attolico, I.; Pascale, S.P.; Bisaccia, F.; Pizzuti, M.; Ostuni, A. Expression of Some ATP-Binding Cassette Transporters in Acute Myeloid Leukemia. Hematol. Rep. 2017, 9, 7406. https://doi.org/10.4081/hr.2017.7406

AMA Style

Salvia AM, Cuviello F, Coluzzi S, Nuccorini R, Attolico I, Pascale SP, Bisaccia F, Pizzuti M, Ostuni A. Expression of Some ATP-Binding Cassette Transporters in Acute Myeloid Leukemia. Hematology Reports. 2017; 9(4):7406. https://doi.org/10.4081/hr.2017.7406

Chicago/Turabian Style

Salvia, Antonella Maria, Flavia Cuviello, Sabrina Coluzzi, Roberta Nuccorini, Immacolata Attolico, Sara Pasquina Pascale, Faustino Bisaccia, Michele Pizzuti, and Angela Ostuni. 2017. "Expression of Some ATP-Binding Cassette Transporters in Acute Myeloid Leukemia" Hematology Reports 9, no. 4: 7406. https://doi.org/10.4081/hr.2017.7406

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