Molecular Basis of α-thalassaemia
Assistant Professor of Genetics, Medical Genetics, University of Athens, St. Sophia’s Children’s Hospital, Athens, Greece
Thalass. Rep. 2011, 1(s2), e13; https://doi.org/10.4081/thal.2011.s2.e13
Submission received: 1 December 2011
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Revised: 15 December 2011
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Accepted: 28 December 2011
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Published: 30 December 2011
Abstract
α-thalassaemia is an autosomal recessive disorder, in which there is impaired production of the a-globin chains of haemoglobin. It is associated with microcytic hypochromic anaemia, and a clinical phenotype varying from almost asymptomatic to a lethal haemolytic anaemia. It is probably the most common single gene disorder worldwide, and is especially frequent in populations originating from the Mediterranean region, SE Asia, Africa, Middle East and Indian subcontinent.
Keywords:
thalassemia; molecular basis
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MDPI and ACS Style
Traeger-Synodinos, J. Molecular Basis of α-thalassaemia. Thalass. Rep. 2011, 1, e13. https://doi.org/10.4081/thal.2011.s2.e13
AMA Style
Traeger-Synodinos J. Molecular Basis of α-thalassaemia. Thalassemia Reports. 2011; 1(s2):e13. https://doi.org/10.4081/thal.2011.s2.e13
Chicago/Turabian StyleTraeger-Synodinos, J. 2011. "Molecular Basis of α-thalassaemia" Thalassemia Reports 1, no. s2: e13. https://doi.org/10.4081/thal.2011.s2.e13
