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Clinics and Practice
Volume 10
Issue 2
10.4081/cp.2020.1248
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Immune Mediated Necrotizing Myopathy: A Rare Complication of Statin Therapy

by
Shady Piedra Abusharar
1,
Prashanth Moku
1,
Sharon Banks
1,2,
Fahad M. Khalid
1,2,
Charles S. Specht
1,2 and
Hyma V. Polimera
1,2,*
1
Penn State College of Medicine, Hershey, PA, USA
2
Penn State Hershey Medical Center, Hershey, PA, USA
*
Author to whom correspondence should be addressed.
Clin. Pract. 2020, 10(2), 1248; https://doi.org/10.4081/cp.2020.1248
Submission received: 17 March 2020 / Revised: 8 June 2020 / Accepted: 22 June 2020 / Published: 30 June 2020

Abstract

Immune mediated necrotizing myopathy (IMNM) is part of the inflammatory myopathies group of diseases and presents with muscle weakness, myalgias and elevated serum creatine phosphokinase (CPK). Statin-induced IMNM is a rare complication. We present a patient with IMNM secondary to simvastatin use. The patient presented with proximal myopathy, dysphagia, and elevated creatinine kinase levels, and was subsequently found to have anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies with a necrotizing process on muscle biopsy. This patient’s case was further complicated by sequelae of multiple disease processes, ultimately leading to deterioration of his health.
Keywords: immune mediated necrotizing myopathy; statins; statin-induced IMNM; inflammatory myopathy immune mediated necrotizing myopathy; statins; statin-induced IMNM; inflammatory myopathy

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MDPI and ACS Style

Abusharar, S.P.; Moku, P.; Banks, S.; Khalid, F.M.; Specht, C.S.; Polimera, H.V. Immune Mediated Necrotizing Myopathy: A Rare Complication of Statin Therapy. Clin. Pract. 2020, 10, 1248. https://doi.org/10.4081/cp.2020.1248

AMA Style

Abusharar SP, Moku P, Banks S, Khalid FM, Specht CS, Polimera HV. Immune Mediated Necrotizing Myopathy: A Rare Complication of Statin Therapy. Clinics and Practice. 2020; 10(2):1248. https://doi.org/10.4081/cp.2020.1248

Chicago/Turabian Style

Abusharar, Shady Piedra, Prashanth Moku, Sharon Banks, Fahad M. Khalid, Charles S. Specht, and Hyma V. Polimera. 2020. "Immune Mediated Necrotizing Myopathy: A Rare Complication of Statin Therapy" Clinics and Practice 10, no. 2: 1248. https://doi.org/10.4081/cp.2020.1248

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