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Clinics and Practice
Volume 2
Issue 1
10.4081/cp.2012.e18
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

The Clinical Response of West Nile Virus Neuroinvasive Disease to Intravenous Immunoglobulin Therapy

by
Zvi Shimoni
1,
Hanna Bin
2,
Shlomo Bulvik
3,
Mark Niven
1,
Rawi Hazzan
4,
Ella Mendelson
5 and
Paul Froom
6,*
1
Department of Internal Medicine B, Laniado Hospital, Netanya, Israel
2
National Center for Zoonotic Viruses, Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical, Tel-Hashomer, Israel
3
Department of Hematology, Laniado Hospital, Netnaya, Israel
4
Department of Internal Medicine D, Rabin Medical Center Campus Beilinson, Petah Tikva, Israel
5
Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical, Tel-Hashomer, Israel
6
Department of Epidemiology and Preventive Medicine, School of Public Health, Tel Aviv University, Ramat Aviv, Israel
*
Author to whom correspondence should be addressed.
Clin. Pract. 2012, 2(1), e18; https://doi.org/10.4081/cp.2012.e18
Submission received: 7 November 2011 / Revised: 4 January 2012 / Accepted: 12 January 2012 / Published: 27 January 2012

Abstract

The aim of the study was to determine whether intravenous gamma globulin (IVIG) treatment is effective in patients with West Nile Virus (WNV) neuroinvasive disease. We contacted hospital based infectious disease experts in Israeli hospitals to identify patients with WNV neuroinvasive disease who were treated with IVIG. The main outcome measure was neurological response after treatment. There were 12 patients who received IVIG and four improved within 48 h. Three patients died, 6 had partial recovery, and 3 recovered completely. Eleven of the 12 patients were infected with Israeli genotypes that are highly homologous to Europe/Africa viruses. The rapid response in some patients suggests that IVIG is effective, and might be used to treat patients with WNV neuroinvasive disease with IVIG.
Keywords: IVIG; West Nile virus; neuroinvasive disease; case series IVIG; West Nile virus; neuroinvasive disease; case series

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MDPI and ACS Style

Shimoni, Z.; Bin, H.; Bulvik, S.; Niven, M.; Hazzan, R.; Mendelson, E.; Froom, P. The Clinical Response of West Nile Virus Neuroinvasive Disease to Intravenous Immunoglobulin Therapy. Clin. Pract. 2012, 2, e18. https://doi.org/10.4081/cp.2012.e18

AMA Style

Shimoni Z, Bin H, Bulvik S, Niven M, Hazzan R, Mendelson E, Froom P. The Clinical Response of West Nile Virus Neuroinvasive Disease to Intravenous Immunoglobulin Therapy. Clinics and Practice. 2012; 2(1):e18. https://doi.org/10.4081/cp.2012.e18

Chicago/Turabian Style

Shimoni, Zvi, Hanna Bin, Shlomo Bulvik, Mark Niven, Rawi Hazzan, Ella Mendelson, and Paul Froom. 2012. "The Clinical Response of West Nile Virus Neuroinvasive Disease to Intravenous Immunoglobulin Therapy" Clinics and Practice 2, no. 1: e18. https://doi.org/10.4081/cp.2012.e18

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