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Clinics and Practice
Volume 4
Issue 1
10.4081/cp.2014.610
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Gangrene of the Digits of the Right Lower Limb in a Patient with Homozygous Sickle Cell Disease and Ulcerative Colitis

by
Angela E. Rankine-Mullings
1,*,
Jennifer M. Knight-Madden
1,
Marvin Reid
2 and
Trevor S. Ferguson
3
1
Sickle Cell Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies, Kingston, Jamaica
2
Tropical Metabolism Research Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies, Kingston, Jamaica
3
Epidemiology Research Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies, Mona, Jamaica
*
Author to whom correspondence should be addressed.
Clin. Pract. 2014, 4(1), 610; https://doi.org/10.4081/cp.2014.610
Submission received: 12 November 2013 / Revised: 19 February 2014 / Accepted: 25 February 2014 / Published: 3 April 2014

Abstract

Thrombosis may play an important role in the pathophysiology of certain complications of sickle cell disease (SCD). While the association between SCD and ulcerative colitis (UC) is still debatable, inflammatory bowel disease is known to be associated with an increased incidence of thromboembolic disease. We report a case of a 16-year old girl known to have homozygous SCD and also diagnosed with UC who presented with digital ischemia of her right lower limb. This led to gangrene and subsequent amputation of the first, second and third digits of that limb. This case highlights that patients with both UC and SCD may have an increased risk of thromboembolism and raises the question as to whether patients with UC and SCD should be screened for thrombophilia.
Keywords: gangrene; homozygous sickle cell disease; ulcerative colitis; digital ischaemia; thromboembolic disease gangrene; homozygous sickle cell disease; ulcerative colitis; digital ischaemia; thromboembolic disease

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MDPI and ACS Style

Rankine-Mullings, A.E.; Knight-Madden, J.M.; Reid, M.; Ferguson, T.S. Gangrene of the Digits of the Right Lower Limb in a Patient with Homozygous Sickle Cell Disease and Ulcerative Colitis. Clin. Pract. 2014, 4, 610. https://doi.org/10.4081/cp.2014.610

AMA Style

Rankine-Mullings AE, Knight-Madden JM, Reid M, Ferguson TS. Gangrene of the Digits of the Right Lower Limb in a Patient with Homozygous Sickle Cell Disease and Ulcerative Colitis. Clinics and Practice. 2014; 4(1):610. https://doi.org/10.4081/cp.2014.610

Chicago/Turabian Style

Rankine-Mullings, Angela E., Jennifer M. Knight-Madden, Marvin Reid, and Trevor S. Ferguson. 2014. "Gangrene of the Digits of the Right Lower Limb in a Patient with Homozygous Sickle Cell Disease and Ulcerative Colitis" Clinics and Practice 4, no. 1: 610. https://doi.org/10.4081/cp.2014.610

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