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Clinics and Practice
Volume 9
Issue 1
10.4081/cp.2019.1126
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

Metabolic Activity of Intestinal Microflora in Patients with Bronchial Asthma

by
Vladimir Ivashkin
1,
Oxana Zolnikova
1,*,
Nino Potskherashvili
2,
Alexander Trukhmanov
1,
Natalia Kokina
2,
Natiya Dzhakhaya
1,
Alla Sedova
1 and
Elena Bueverova
1
1
Chair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
2
Vasilenko Clinic of Internal Disease Propedeutics, Gastroenterology, and Hepatology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
*
Author to whom correspondence should be addressed.
Clin. Pract. 2019, 9(1), 1126; https://doi.org/10.4081/cp.2019.1126
Submission received: 12 January 2019 / Revised: 18 February 2019 / Accepted: 19 February 2019 / Published: 28 February 2019

Abstract

The gut microbiota plays the important role to support the immunological tolerance. To study a metabolic activity of the intestinal microflora the 44 patients suffering from bronchial asthma and 17 healthy volunteers were tested. The short-chain fatty acids (SCFA) spectrum was determined using the method of gas-liquid chromatographic analysis. We have detected a significant decrease the total content of the fatty acids in the feces (P<0.001), the absolute concentrations of the individual acids (acetate, propionate, butyrate; P<0.001) and the total content of isoacids (P<0.001) for all of the patients with bronchial asthma in the study, regardless of the phenotype. The anaerobic type of the SCFA spectrum was detected for the majority (83%) of the patients tested. The aerobic type of the SCFA metabolic profile was detected for another part (17%) of the patients tested. Being detected the parameters change could play the principal role as for the bronchial asthma course as to support the organism sensibilisation.
Keywords: short-chain fatty acids; gut microbiota; bronchial asthma; immunomodulation short-chain fatty acids; gut microbiota; bronchial asthma; immunomodulation

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MDPI and ACS Style

Ivashkin, V.; Zolnikova, O.; Potskherashvili, N.; Trukhmanov, A.; Kokina, N.; Dzhakhaya, N.; Sedova, A.; Bueverova, E. Metabolic Activity of Intestinal Microflora in Patients with Bronchial Asthma. Clin. Pract. 2019, 9, 1126. https://doi.org/10.4081/cp.2019.1126

AMA Style

Ivashkin V, Zolnikova O, Potskherashvili N, Trukhmanov A, Kokina N, Dzhakhaya N, Sedova A, Bueverova E. Metabolic Activity of Intestinal Microflora in Patients with Bronchial Asthma. Clinics and Practice. 2019; 9(1):1126. https://doi.org/10.4081/cp.2019.1126

Chicago/Turabian Style

Ivashkin, Vladimir, Oxana Zolnikova, Nino Potskherashvili, Alexander Trukhmanov, Natalia Kokina, Natiya Dzhakhaya, Alla Sedova, and Elena Bueverova. 2019. "Metabolic Activity of Intestinal Microflora in Patients with Bronchial Asthma" Clinics and Practice 9, no. 1: 1126. https://doi.org/10.4081/cp.2019.1126

APA Style

Ivashkin, V., Zolnikova, O., Potskherashvili, N., Trukhmanov, A., Kokina, N., Dzhakhaya, N., Sedova, A., & Bueverova, E. (2019). Metabolic Activity of Intestinal Microflora in Patients with Bronchial Asthma. Clinics and Practice, 9(1), 1126. https://doi.org/10.4081/cp.2019.1126

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