The Role of Toxins in the Pursuit for Novel Analgesics
Abstract
:1. Introduction
2. Transient Receptor Potential Vanilloid 1 (TRPV1)
3. Transient Receptor Potential Ankyrin 1 (TRPA1)
4. Acid-Sensing Ion Channels (ASICs)
5. Voltage-Gated Sodium Channels
6. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Toxin | Nociceptive Effect | Pain Model |
---|---|---|
Capsaicin Capsicum family | Analgesia (following pain) | Acute (rats) [56,92,93]. Neuropathic pain (humans) [94,95,96,97,98]. |
RTX Euphorbia resinifera | Analgesia (following pain) | Acute (pigs, mice and rats) [99,100,101,102]. Inflammatory (dogs, rats and mice) [65,101,102]. Cancer-related pain (humans and dogs) [65,103]. |
VaTx1-3 Psalmopoeus cambridgei | Pain | Acute (mice) [68]. |
DkTx Ornithoctonus huwena | NA | - |
RhTx Scolopendra subspinipes mutilans | Pain | Acute (mice) [75]. |
BmP01 Mesobuthus martensii | Pain | Acute (mice) [76]. |
APHC1,3 Heteractis crispa | Analgesia | Acute (mice) [55]. Inflammatory (mice) [55] |
AG489 Agelenopsis aperta | NA | - |
Toxin | Nociceptive Effect | Pain Model |
---|---|---|
ProTx-I Thrixopelma pruriens | NA | - |
Phα1β Phoneutria nigriventer | Analgesia | Acute [148,150]. Inflammatory (mice) [148,150,153]. Neuropathic (rats) [148,150,153,171]. Post-operative pain (mice) [149]. Cancer-related pain (mice and rats) [151,152,153]. |
Ms 9a-1 metridium senile | Analgesia | Acute and inflammatory (mice) [144]. |
Ueq 12-1 metridium senile | Analgesia | Acute and inflammatory (mice) [144,157]. |
Crotalphine Crotalus durissus terrificus | Analgesia | Acute (mice) [161]. Inflammatory (rats) [158,159,161]. Neuropathic (rats) [160]. Cancer-related pain (rats) [162]. |
Gsmtx-4 Grammostola spatulata | NA | - |
Toxin | Nociceptive Effect | Pain Model |
---|---|---|
PcTx1 Psalmopoeus cambridgei | Analgesia | Acute (mice) [193]. Inflammatory (mice) [193]. Neuropathic (mice and rats) [193]. Visceral (rats) [194]. |
Hi1a Hadronyche infensa | NA | - |
Hm3a Heteroscodra maculata | NA | - |
APETx2 Anthopleura elegantissima | Analgesia | Inflammatory (rats) [181,210,211]. Post-operative pain, rats [202]. |
Mambalgin1-3 Dendroaspis polylepis Dendroaspis angusticeps | Analgesia | Acute (mice) [195]. Inflammatory (mice) [195]. |
MitTx Micrurus tener tener | Pain | Acute (mice) [208]. |
Toxin | Nociceptive Effect | Pain Model |
---|---|---|
Tetrodotoxin Tetraodontidae | Analgesia | Inflammatory (mice and rats) [273,274,276]. Neuropathic (mice and rats) [271,273,275,276]. Visceral (mice and rats) [67,276]. Cancer-related pain (mice and humans) [272,273,277,278]. |
ProTx-II Thrixopelma pruriens | Analgesia | Acute and inflammatory (rats) [285]. Diabetic neuropathic pain (mice) [284]. |
β-TRTX-Gr1b Grammostola rosea | Analgesia | Acute and inflammatory (rats) [289]. |
μ-theraphotoxin-Pn3a Pamphobeteus nigricolor | Analgesia(only when co-administrated with opioids) | Acute and inflammatory (mice and rats) [299]. |
μO-conotoxin MrVIB Conus marmoreus | Analgesia | Acute (rats) [301]. Inflammatory (rats) [302]. Post-operative pain (rats) [301]. Neuropathic (rats) [302]. |
δ-theraphotoxin-Hm1a δ-theraphotoxin-Hm1b Heteroscodra maculata | Pain | Pain and mechanical hypersensitivity (mice) [245]. |
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Maatuf, Y.; Geron, M.; Priel, A. The Role of Toxins in the Pursuit for Novel Analgesics. Toxins 2019, 11, 131. https://doi.org/10.3390/toxins11020131
Maatuf Y, Geron M, Priel A. The Role of Toxins in the Pursuit for Novel Analgesics. Toxins. 2019; 11(2):131. https://doi.org/10.3390/toxins11020131
Chicago/Turabian StyleMaatuf, Yossi, Matan Geron, and Avi Priel. 2019. "The Role of Toxins in the Pursuit for Novel Analgesics" Toxins 11, no. 2: 131. https://doi.org/10.3390/toxins11020131