Next Article in Journal
Comparative Transcriptome Analysis of Toxic and Non-Toxic Nassarius Communities and Identification of Genes Involved in TTX-Adaptation
Next Article in Special Issue
Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-Producing Escherichia coli (STEC) Strain B2F1 in Streptomycin (Str)-Treated Mice
Previous Article in Journal
Evidence for the Range Expansion of Ciguatera in French Polynesia: A Revisit of the 2009 Mass-Poisoning Outbreak in Rapa Island (Australes Archipelago)
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Toxins
Volume 12
Issue 12
10.3390/toxins12120760
toxins-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function

by
Shahnawaz Butt
,
Mazen Saleh
and
Jeffrey Gagnon
*
Department of Biology, Laurentian University, 935 Ramsey Lake Rd., Sudbury, ON P3E 2C6, Canada
*
Author to whom correspondence should be addressed.
Toxins 2020, 12(12), 760; https://doi.org/10.3390/toxins12120760
Submission received: 1 October 2020 / Revised: 24 November 2020 / Accepted: 26 November 2020 / Published: 2 December 2020
(This article belongs to the Special Issue Escherichia coli Toxins and Intestinal Diseases)
Browse Figures
Review Reports Versions Notes

Abstract

Enterotoxigenic Escherichia coli (ETEC) produces the heat-stable enterotoxin b (STb), which is responsible for secretory diarrhea in humans and animals. This toxin is secreted within the intestinal lumen of animals and humans following ETEC colonization, becoming active on enterocytes and altering fluid homeostasis. Several studies have outlined the nature of this toxin and its effects on gut health and the integrity of the intestinal epithelium. This review summarizes the mechanisms of how STb alters the gastrointestinal tract. These include the manipulation of mucosal tight junction protein integrity, the formation of enterocyte cellular pores and toxin internalization and the stimulation of programmed cell death. We conclude with insights into the potential link between STb intoxication and altered gut hormone regulation, and downstream physiology.
Keywords: Escherichia coli; ETEC; enterotoxigenic; enterotoxins; heat-stable; gastrointestinal; internalization; tight junction; apoptosis; hormones Escherichia coli; ETEC; enterotoxigenic; enterotoxins; heat-stable; gastrointestinal; internalization; tight junction; apoptosis; hormones

Share and Cite

MDPI and ACS Style

Butt, S.; Saleh, M.; Gagnon, J. Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function. Toxins 2020, 12, 760. https://doi.org/10.3390/toxins12120760

AMA Style

Butt S, Saleh M, Gagnon J. Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function. Toxins. 2020; 12(12):760. https://doi.org/10.3390/toxins12120760

Chicago/Turabian Style

Butt, Shahnawaz, Mazen Saleh, and Jeffrey Gagnon. 2020. "Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function" Toxins 12, no. 12: 760. https://doi.org/10.3390/toxins12120760

APA Style

Butt, S., Saleh, M., & Gagnon, J. (2020). Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function. Toxins, 12(12), 760. https://doi.org/10.3390/toxins12120760

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop