An Update on Clostridioides difficile Binary Toxin
Abstract
:1. Introduction
2. Clostridioides difficile Binary Toxin (CDT)
3. In Vitro Effects of CDT
4. CDT-Producing Ribotypes
5. Clinical Relevance
6. Implications of CDT in Laboratory Diagnosis
7. CDT as a Therapeutic Target
8. Concluding Remarks
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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RT | Toxin Genotype | ST | Clade | Characteristics | References |
---|---|---|---|---|---|
023 | tcdA+, tcdB+, cdtA+, cdtB+ | 5, 22, 25 | 3 | Resistance to erythromycin, levofloxacin, and moxifloxacin. Reports from USA, Northern and Eastern Europe. | [45,46,47] |
027/176 | tcdA+, tcdB+, cdtA+, cdtB+ | 1 | 2 | Strain associated with increased morbidity and mortality. Reports from Korea, Singapore, Austria, Belgium, Denmark, Finland, France, Germany, Hungary, Ireland, Luxembourg, The Netherlands, Norway, Spain, Sweden, UK, Chile, Panama, Costa Rica, Mexico, Japan, China. | [33,48,49,50,51,52,53,54,55] |
033 | tcdA−, tcdB−, cdtA+, cdtB+ | ND | 5 | Isolated from a young patient with ulcerative colitis and severe diarrhea in Australia. | [56,57] |
078/126 | tcdA+, tcdB+, cdtA+, cdtB+ | 11 | 5 | Community-associated and zoonotic strain with increased morbidity and mortality. Reports from France, Italy, Germany, Taiwan, Czech Republic, Korea, Japan, Australia. | [5,40,41,48,50,57,58,59,60,61] |
244 | tcdA+, tcdB+, cdtA+, cdtB+ | 41 | 2 | Community-associated; cause of outbreaks. Reports in Australia, New Zealand. | [44,45,62] |
251 | tcdA+, tcdB+, cdtA+, cdtB+ | 231 | 2 | Isolated from three patients in Australia with severe diarrhea, recurrent disease, and one death. | [63] |
826 | tcdA+, tcdB+, cdtA+, cdtB+ | ND | 5 | Identified in an outbreak in The Netherlands, associated with recurrent and severe disease in two of five patients | [64] |
ND | tcdA+, tcdB+, cdtA+, cdtB+ | 201 | 3 | Isolated from a patient in China, with a severe clinical phenotype; it exhibits a faster germination rate, higher motility, and a higher biofilm formation than RT027 and RT078. | [62,65,66] |
ND | tcdA−, tcdB−, cdtA+, cdtB+ | 11 | 5 | Isolated from a patient in Germany, with eight episodes of CDI ranging from mild to severe symptoms. | [67] |
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Martínez-Meléndez, A.; Cruz-López, F.; Morfin-Otero, R.; Maldonado-Garza, H.J.; Garza-González, E. An Update on Clostridioides difficile Binary Toxin. Toxins 2022, 14, 305. https://doi.org/10.3390/toxins14050305
Martínez-Meléndez A, Cruz-López F, Morfin-Otero R, Maldonado-Garza HJ, Garza-González E. An Update on Clostridioides difficile Binary Toxin. Toxins. 2022; 14(5):305. https://doi.org/10.3390/toxins14050305
Chicago/Turabian StyleMartínez-Meléndez, Adrián, Flora Cruz-López, Rayo Morfin-Otero, Héctor J. Maldonado-Garza, and Elvira Garza-González. 2022. "An Update on Clostridioides difficile Binary Toxin" Toxins 14, no. 5: 305. https://doi.org/10.3390/toxins14050305