Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows
Abstract
:1. Introduction
2. Materials and Methods
2.1. Blood Sample Preparation
2.2. Fabrication of a Microfluidic Device and Experimental Procedure
2.3. Quantification of Image Intensity and Blood Flow-Rate
2.4. Statistical Analysis
3. Results and Discussion
3.1. Effect of Air Cavity Adjusted inside the ACS on Pressure Index (PI)
3.2. Pressure Index Variations for Blood Samples Composed of GA-Stimulated Hardened RBCs
3.3. Effect of Hematocrit and Base Solutions on Pressure and RBCs aggregation Indices
3.4. Quantification of RBC Aggregation-Enhanced Blood Samples
4. Conclusions
Supplementary Materials
Funding
Conflicts of Interest
References
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Blood Biophysical Properties | Blood Delivery Tools | Issues | References |
---|---|---|---|
RBCs aggregation, and blood pressure | Disposable air-compressed pump (on–off flow control) |
| [62] |
RBCs aggregation, RBC deformability, and hematocrit | Syringe pump (periodic on–off control) |
| [63] |
RBCs aggregation, and blood viscosity | Two syringe pumps (constant flow rate) |
| [52] |
RBCs aggregation, and ESR | Air suction syringe, or syringe pump |
| [18,55,57] |
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Kang, Y.J. Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows. Micromachines 2019, 10, 577. https://doi.org/10.3390/mi10090577
Kang YJ. Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows. Micromachines. 2019; 10(9):577. https://doi.org/10.3390/mi10090577
Chicago/Turabian StyleKang, Yang Jun. 2019. "Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows" Micromachines 10, no. 9: 577. https://doi.org/10.3390/mi10090577