Next Article in Journal
Large-Scale Piezoelectric-Based Systems for More Electric Aircraft Applications
Next Article in Special Issue
Ultrasound-Based Scaffold-Free Core-Shell Multicellular Tumor Spheroid Formation
Previous Article in Journal
Experimental Analysis of Laser Micromachining of Microchannels in Common Microfluidic Substrates
Previous Article in Special Issue
Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Micromachines
Volume 12
Issue 2
10.3390/mi12020139
micromachines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing

by
Leslie Donoghue
1,2,†,
Khanh T. Nguyen
1,2,†,
Caleb Graham
1,2,† and
Palaniappan Sethu
1,2,*
1
Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35233, USA
2
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Micromachines 2021, 12(2), 139; https://doi.org/10.3390/mi12020139
Submission received: 24 December 2020 / Revised: 23 January 2021 / Accepted: 26 January 2021 / Published: 28 January 2021
(This article belongs to the Special Issue Microfluidics: Tissue Chips and Microphysiological Systems)
Browse Figures
Versions Notes

Abstract

Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies. This review highlights the basic definitions of TCs and MPSs, examines four major organs/tissues, identifies critical parameters for organization and function (tissue organization, blood flow, and physical stresses), reviews current microfluidic approaches to recreate tissues, and discusses current shortcomings and future directions for the development and application of these technologies. The organs emphasized are those involved in the metabolism or excretion of drugs (hepatic and renal systems) and organs sensitive to drug toxicity (cardiovascular system). This article examines the microfluidic/microfabrication approaches for each organ individually and identifies specific examples of TCs. This review will provide an excellent starting point for understanding, designing, and constructing novel TCs for possible integration within MPS.
Keywords: tissue chips; microphysiological systems; microfluidics; organ-on-a-chip; tissue-on-a-chip; body-on-a-chip tissue chips; microphysiological systems; microfluidics; organ-on-a-chip; tissue-on-a-chip; body-on-a-chip

Share and Cite

MDPI and ACS Style

Donoghue, L.; Nguyen, K.T.; Graham, C.; Sethu, P. Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing. Micromachines 2021, 12, 139. https://doi.org/10.3390/mi12020139

AMA Style

Donoghue L, Nguyen KT, Graham C, Sethu P. Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing. Micromachines. 2021; 12(2):139. https://doi.org/10.3390/mi12020139

Chicago/Turabian Style

Donoghue, Leslie, Khanh T. Nguyen, Caleb Graham, and Palaniappan Sethu. 2021. "Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing" Micromachines 12, no. 2: 139. https://doi.org/10.3390/mi12020139

APA Style

Donoghue, L., Nguyen, K. T., Graham, C., & Sethu, P. (2021). Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing. Micromachines, 12(2), 139. https://doi.org/10.3390/mi12020139

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop