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Article

Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate

by
Claudia Trejo-Soto
1,* and
Aurora Hernández-Machado
2,3,4
1
Instituto de Física, Pontificia Universidad Católica de Valparaiso, Casilla 4059, Chile
2
Departament de Física de la Materia Condensada, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain
3
Centre de Recerca Matemàtica, Edifici C, Campus de Bellaterra, 08193 Bellaterra, Spain
4
Institute of Nanoscience and Nanotechnology (IN2UB), Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Micromachines 2022, 13(3), 357; https://doi.org/10.3390/mi13030357
Submission received: 23 December 2021 / Revised: 1 February 2022 / Accepted: 2 February 2022 / Published: 24 February 2022
(This article belongs to the Special Issue Nanostructured Surfaces and Devices for Biomedical Applications)

Abstract

The rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood in a microchannel, we determine the viscosity of different samples of blood. In this work, we present two methods that successfully normalize the viscosity of blood for a single and for different donors, first according to the concentration of erythrocytes and second according to the shear rate. The proposed methodology is able to predict the health conditions of the blood samples by introducing a non-dimensional coefficient that accounts for the response to shear rate of the different donors blood samples. By means of these normalization methods, we were able to determine the differences between the red blood cells of the samples and define a range where healthy blood samples can be described by a single behavior.
Keywords: blood; viscosity; microfluidics; hematocrit; shear rate blood; viscosity; microfluidics; hematocrit; shear rate

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MDPI and ACS Style

Trejo-Soto, C.; Hernández-Machado, A. Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate. Micromachines 2022, 13, 357. https://doi.org/10.3390/mi13030357

AMA Style

Trejo-Soto C, Hernández-Machado A. Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate. Micromachines. 2022; 13(3):357. https://doi.org/10.3390/mi13030357

Chicago/Turabian Style

Trejo-Soto, Claudia, and Aurora Hernández-Machado. 2022. "Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate" Micromachines 13, no. 3: 357. https://doi.org/10.3390/mi13030357

APA Style

Trejo-Soto, C., & Hernández-Machado, A. (2022). Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate. Micromachines, 13(3), 357. https://doi.org/10.3390/mi13030357

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