Born out of Fire and Ice: Polymorph Studies of the Antiviral Famciclovir
Abstract
:1. Introduction
2. Results and Discussion
2.1. Powder Diffraction Studies
2.2. Single-Crystal Diffraction
3. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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D | H | A | d(D-H)/Å | d(H-A)/Å | d(D-A)/Å | D-H-A/° |
---|---|---|---|---|---|---|
N10 | H10A | N6 1 | 0.883(19) | 2.180(19) | 3.0595(17) | 173.9(16) |
N10 | H10B | N3 2 | 0.902(19) | 2.187(19) | 3.0861(18) | 174.6(17) |
C2 | H2 | O18 3 | 0.95 | 2.28 | 3.2222(19) | 173 |
C5 | H5 | N8 4 | 0.95 | 2.51 | 3.2894(18) | 140 |
C17 | H17C | O20 5 | 0.98 | 2.58 | 3.472(2) | 152 |
C22 | H22C | N8 5 | 0.98 | 2.41 | 3.384(3) | 176 |
Method | Crystal Structure | Melting Point | Lit. | |
---|---|---|---|---|
form I | (a) Heating to 70 °C (b) Recrystallization from isopropanol, diethylether or acetonitrile | Yes, this work | Endothermic peak at 104 °C | [18] |
form II | Recrystallization of form I from a solution in n-butanol or ethanol by cooling | No | Endothermic peak at 104 °C | [18] |
form III | Recrystallization of form I from a solution in methanol | No | Endothermic peaks at 84 °C and 100 °C | [18] |
form IV | Step 1: heating to 110 °C; Step 2: cooling to −50 °C | No | N/A | N/A |
Monohydrate | Recrystallization from water | Yes, CSD code: YACHAL | 87–95 °C | [15] |
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Vella-Zarb, L.; Baisch, U. Born out of Fire and Ice: Polymorph Studies of the Antiviral Famciclovir. Crystals 2021, 11, 129. https://doi.org/10.3390/cryst11020129
Vella-Zarb L, Baisch U. Born out of Fire and Ice: Polymorph Studies of the Antiviral Famciclovir. Crystals. 2021; 11(2):129. https://doi.org/10.3390/cryst11020129
Chicago/Turabian StyleVella-Zarb, Liana, and Ulrich Baisch. 2021. "Born out of Fire and Ice: Polymorph Studies of the Antiviral Famciclovir" Crystals 11, no. 2: 129. https://doi.org/10.3390/cryst11020129