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Crystals
Volume 15
Issue 7
10.3390/cryst15070627
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Discovery and Structural Characterization of a Novel Polymorph (Form III) of Alclometasone Dipropionate

by
Gianfranco Lopopolo
1,†,
M. Giovanna E. Papadopoulos
2,†,
Corrado Cuocci
2,
Giuseppe F. Mangiatordi
2,
Antonio Lopalco
3,
Emanuele Attolino
1 and
Rosanna Rizzi
2,*
1
Research & Development Department, Newchem SpA, via Roveggia 47, 37136 Verona, Italy
2
Institute of Crystallography-CNR, Via G. Amendola 122/o, 70126 Bari, Italy
3
Department of Pharmacy—Pharmaceutical Sciences, University of Bari, via E. Orabona 4, 70125 Bari, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Crystals 2025, 15(7), 627; https://doi.org/10.3390/cryst15070627 (registering DOI)
Submission received: 23 May 2025 / Revised: 3 July 2025 / Accepted: 4 July 2025 / Published: 5 July 2025
(This article belongs to the Special Issue Celebrating the 10th Anniversary of International Crystallography)
Versions Notes

Abstract

This study reports the discovery and structural characterization of a novel polymorph, designated as Form III, of Alclometasone dipropionate, a corticosteroid commonly used in the treatment of inflammatory dermatoses. Form III was obtained by modifying the crystallization conditions reported in prior art and was thoroughly characterized using Powder X-ray Diffraction (PXRD), Fourier Transform Infrared (FT-IR) spectroscopy, melting-point determination, Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), including its first derivative (DTG), optical microscopy, and Scanning Electron Microscopy (SEM). In parallel, pure Form II, previously observed only in mixtures with Form I, was successfully isolated and characterized using the same analytical techniques. Both forms were compared in terms of structural, thermal, and morphological properties. PXRD analysis revealed that Form III crystallizes in a triclinic system; FT-IR spectroscopy revealed unique vibrational signatures, and microscopy showed rod-like crystal morphology. The discovery of Form III expands the current understanding of the solid-state landscape of Alclometasone dipropionate and opens opportunities for the identification of new industrial purification methods for the compound.
Keywords: alclometasone dipropionate; polymorphism; crystal structure alclometasone dipropionate; polymorphism; crystal structure

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MDPI and ACS Style

Lopopolo, G.; Papadopoulos, M.G.E.; Cuocci, C.; Mangiatordi, G.F.; Lopalco, A.; Attolino, E.; Rizzi, R. Discovery and Structural Characterization of a Novel Polymorph (Form III) of Alclometasone Dipropionate. Crystals 2025, 15, 627. https://doi.org/10.3390/cryst15070627

AMA Style

Lopopolo G, Papadopoulos MGE, Cuocci C, Mangiatordi GF, Lopalco A, Attolino E, Rizzi R. Discovery and Structural Characterization of a Novel Polymorph (Form III) of Alclometasone Dipropionate. Crystals. 2025; 15(7):627. https://doi.org/10.3390/cryst15070627

Chicago/Turabian Style

Lopopolo, Gianfranco, M. Giovanna E. Papadopoulos, Corrado Cuocci, Giuseppe F. Mangiatordi, Antonio Lopalco, Emanuele Attolino, and Rosanna Rizzi. 2025. "Discovery and Structural Characterization of a Novel Polymorph (Form III) of Alclometasone Dipropionate" Crystals 15, no. 7: 627. https://doi.org/10.3390/cryst15070627

APA Style

Lopopolo, G., Papadopoulos, M. G. E., Cuocci, C., Mangiatordi, G. F., Lopalco, A., Attolino, E., & Rizzi, R. (2025). Discovery and Structural Characterization of a Novel Polymorph (Form III) of Alclometasone Dipropionate. Crystals, 15(7), 627. https://doi.org/10.3390/cryst15070627

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