GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure
Abstract
:1. Introduction
2. β-Adrenergic Regulation of Cardiac Function
2.1. G Protein-Coupled Receptors
2.2. Cardiac β-Adrenergic Receptors
2.3. β-Adrenergic Receptor in HF
3. Pathophysiological Roles of GRK2 and GRK5 in the Heart
3.1. GRK Isoforms
3.2. Role of GRK2 and GRK5 in Cardiac Remodeling and Heart Failure
3.2.1. GRK2
3.2.2. GRK5
4. Role of Epac1 in Cardiac Pathophysiology
4.1. Epac Structure and Activation
4.2. Epac Pharmacological Tools
4.3. Role of Epac in Cardiac Disease
5. Epac1 and GRK Molecular Complex Formation in Cardiac Remodeling
5.1. Epac1, CaMKII and β-Arrestin Complex
5.2. Epac1 and GRK5
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Laudette, M.; Formoso, K.; Lezoualc’h, F. GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure. Cells 2021, 10, 154. https://doi.org/10.3390/cells10010154
Laudette M, Formoso K, Lezoualc’h F. GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure. Cells. 2021; 10(1):154. https://doi.org/10.3390/cells10010154
Chicago/Turabian StyleLaudette, Marion, Karina Formoso, and Frank Lezoualc’h. 2021. "GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure" Cells 10, no. 1: 154. https://doi.org/10.3390/cells10010154