Next Article in Journal
Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival
Next Article in Special Issue
Stem Cells as a Source of Pancreatic Cells for Production of 3D Bioprinted Bionic Pancreas in the Treatment of Type 1 Diabetes
Previous Article in Journal
White Matter Interstitial Neurons in the Adult Human Brain: 3% of Cortical Neurons in Quest for Recognition
Previous Article in Special Issue
Generation of Functional Vascular Endothelial Cells and Pericytes from Keratinocyte Derived Human Induced Pluripotent Stem Cells
 
 
Review
Peer-Review Record

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

by Stephanie Bourgeois 1,†, Toshiaki Sawatani 2,†, Annelore Van Mulders 1, Nico De Leu 1,3,4, Yves Heremans 1, Harry Heimberg 1, Miriam Cnop 2,5 and Willem Staels 1,6,*
Reviewer 1: Anonymous
Reviewer 2:
Submission received: 30 November 2020 / Accepted: 12 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue Pluripotent Stem Cells for Regenerative Medicine)

Round 1

Reviewer 1 Report

This is a well-written, comprehensive, and balanced review on the current status and future prospects of cell therapy for diabetes, based primarily on allotransplantation of beta-like cells generated from pluripotent stem cells. It focuses on the challenges to generation of functional beta cells, their purification from undifferentiated cells with tumorigenic potential, and their protection from graft rejection. The reviewed data are summarized in useful tables. Given the great potential of cell replacement for diabetes therapy, this is a timely and important review.

Reviewer 2 Report

A concise state-of-the-art and well-written review summarizing current knowledge and challenges related to stem cell therapy for diabetes. Congrats.

Back to TopTop