Next Article in Journal
Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review
Next Article in Special Issue
Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes
Previous Article in Journal
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer’s Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin
Previous Article in Special Issue
Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 10
Issue 11
10.3390/cells10113262
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Interface between Cell Signaling Pathways and Pregnane X Receptor

by
Robert S. Rogers
1,
Annemarie Parker
1,
Phill D. Vainer
1,
Elijah Elliott
1,
Dakota Sudbeck
1,
Kaushal Parimi
2,
Venkata P. Peddada
1,
Parker G. Howe
1,
Nick D’Ambrosio
1,
Gregory Ruddy
1,
Kaitlin Stackable
1,
Megan Carney
1,
Lauren Martin
1,
Thomas Osterholt
1 and
Jeff L. Staudinger
1,*
1
Division of Basic Sciences, Farber-McIntire Campus, College of Osteopathic Medicine, Kansas City University, Joplin, MO 64804, USA
2
Thomas Jefferson Independent Day School, Joplin, MO 64801, USA
*
Author to whom correspondence should be addressed.
Cells 2021, 10(11), 3262; https://doi.org/10.3390/cells10113262
Submission received: 30 October 2021 / Revised: 15 November 2021 / Accepted: 16 November 2021 / Published: 22 November 2021
(This article belongs to the Collection Current Trends in Xenobiotic Sensing Nuclear Receptor Research—The Many Facets of PXR and CAR)
Browse Figures
Versions Notes

Abstract

Highly expressed in the enterohepatic system, pregnane X receptor (PXR, NR1I2) is a well-characterized nuclear receptor (NR) that regulates the expression of genes in the liver and intestines that encode key drug metabolizing enzymes and drug transporter proteins in mammals. The net effect of PXR activation is to increase metabolism and clear drugs and xenobiotics from the body, producing a protective effect and mediating clinically significant drug interaction in patients on combination therapy. The complete understanding of PXR biology is thus important for the development of safe and effective therapeutic strategies. Furthermore, PXR activation is now known to specifically transrepress the inflammatory- and nutrient-signaling pathways of gene expression, thereby providing a mechanism for linking these signaling pathways together with enzymatic drug biotransformation pathways in the liver and intestines. Recent research efforts highlight numerous post-translational modifications (PTMs) which significantly influence the biological function of PXR. However, this thrust of research is still in its infancy. In the context of gene-environment interactions, we present a review of the recent literature that implicates PXR PTMs in regulating its clinically relevant biology. We also provide a discussion of how these PTMs likely interface with each other to respond to extracellular cues to appropriately modify PXR activity.
Keywords: nuclear receptor; pregnane X receptor; xenobiotics; cell signaling; phosphorylation; SUMOylation; ubiquitination; acetylation; PARylation nuclear receptor; pregnane X receptor; xenobiotics; cell signaling; phosphorylation; SUMOylation; ubiquitination; acetylation; PARylation
Graphical Abstract

Share and Cite

MDPI and ACS Style

Rogers, R.S.; Parker, A.; Vainer, P.D.; Elliott, E.; Sudbeck, D.; Parimi, K.; Peddada, V.P.; Howe, P.G.; D’Ambrosio, N.; Ruddy, G.; et al. The Interface between Cell Signaling Pathways and Pregnane X Receptor. Cells 2021, 10, 3262. https://doi.org/10.3390/cells10113262

AMA Style

Rogers RS, Parker A, Vainer PD, Elliott E, Sudbeck D, Parimi K, Peddada VP, Howe PG, D’Ambrosio N, Ruddy G, et al. The Interface between Cell Signaling Pathways and Pregnane X Receptor. Cells. 2021; 10(11):3262. https://doi.org/10.3390/cells10113262

Chicago/Turabian Style

Rogers, Robert S., Annemarie Parker, Phill D. Vainer, Elijah Elliott, Dakota Sudbeck, Kaushal Parimi, Venkata P. Peddada, Parker G. Howe, Nick D’Ambrosio, Gregory Ruddy, and et al. 2021. "The Interface between Cell Signaling Pathways and Pregnane X Receptor" Cells 10, no. 11: 3262. https://doi.org/10.3390/cells10113262

APA Style

Rogers, R. S., Parker, A., Vainer, P. D., Elliott, E., Sudbeck, D., Parimi, K., Peddada, V. P., Howe, P. G., D’Ambrosio, N., Ruddy, G., Stackable, K., Carney, M., Martin, L., Osterholt, T., & Staudinger, J. L. (2021). The Interface between Cell Signaling Pathways and Pregnane X Receptor. Cells, 10(11), 3262. https://doi.org/10.3390/cells10113262

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop